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iNOS抑制剂对兔关节软骨修复组织胶原表达的影响 |
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impregnated with rhBMP，eight were filled with a collagen fibrin glue impregnated with rhBMP and hypodermic injection with 5 mg/kg²1/12 h²1 SMT.The animals were killed at one²year postperatively.The tissue sections were stained with Sirius²Red against collagen type²Ⅰand type²Ⅱwhich analyzed by Quantiment 500.Cartilage thickness was measured by Quantiment 500 too.Results One²year after collagen fibrin glue with rhBMP and with hypodermic injection SMT，collagen type²Ⅰ expression of repair tissue in SMT group(65.9％) was less than in BMP group(88.5％) and the control(94.6％)，and collagen type²Ⅱ (30.7％) was more than in BMP group(10.8％) and the control(4.5％).Cartilage thickness of SMT group(1.85±0.56) mm was significant higher than BMP group(0.67±0.31) mm and the control(0.24±0.10) mm.Conclusion NOS inhibitor SMT could increase collagen type²Ⅰexpression and decrease collagen type²Ⅱexpression，as well as make phenotype good.
Key words：nitric oxide synthase；inhibitor；cartilage；s²methylisothiourea；collagen
一氧化氮(nitric oxide，NO)是活泼的自由基分子，参与多种组织的代谢调节。关节软骨自身修复能力十分有限，关节软骨损伤通常会导致更严重的关节软骨退变，既往研究已采用多种方法来修复和重建关节软骨，许多技术已被广泛应用于临床。而一氧化氮合酶(nitric oxide synthase，NOS) 抑制剂有助于软骨组织修复。因此本文应用苦味酸²天狼猩红染色，研究软骨修复组织中胶原纤维的表达变化，了解NOS抑制上一页 [1] [2] [3] [4] [5] 下一页
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