养血益脑饮联合盐酸氟西汀胶囊治疗脑梗死后抑郁症68例

【摘要】  　　目的 观察养血益脑饮联合盐酸氟西汀胶囊治疗脑梗死后抑郁症的临床疗效。方法 122例脑梗死后抑郁症患者随机分为2组。治疗组68例予养血益脑饮联合盐酸氟西汀胶囊治疗；对照组54例予盐酸氟西汀胶囊治疗；2组均针对原发病进行常规治疗及浅层心理治疗，加强神经康复锻炼。4周为1个疗程。结果 分别采用汉密尔顿抑郁量表、神经功能缺损程度比较差异有统计学意义（P＜0.05），治疗组优于对照组；治疗组不良反应少。结论 养血益脑饮联合盐酸氟西汀胶囊可明显改善脑梗死后抑郁障碍的程度，促进神经功能康复。

【关键词】  脑梗塞 抑郁症 氟西汀 汤剂 中西医结合疗法

　　Effect of combination of Yangxueyinaoyin and fluoxertine hydrochloride on depression after cerebral infarction 

　　ZHAO Wenxue, ZHANG Guangqiang, ZHANG Guangpu, et al.

　　Department of TCM, Mentougou District Hospital of Beijing, Beijing  102300

　　【Abstract】  Objective  To observe the effect combination of Yangxueyinaoyin and fluoxertine hydrochloride on depression after cerebral infarction. Methods  122 cases with depression after cerebral infarction were randomly divided into two groups. Patients in control group (n=54) were treated by fluoxertine hydrochloride. Patients in treatment group (n=68) were treated by combination of Yangxueyinaoyin and fluoxertine hydrochloride. All patients in two groups were treated by conventional therapy and psychotherapy. Results  There were significant differences between control group and treatment group on Hamilton s depression scale and neurologic impairment degree. Improvement of symptoms in treatment group was superior to that in control group (P<0.05). Conclusion  Combination of Yangxueyinaoyin and fluoxertine hydrochloride can improve degree of depression after cerebral infarction, and facilitate nervous functional rehabilitation.

　　【Key words】  Cerebral infarction; Depressive disorder; Fluoxetine; Decoction; Combination of TCM with Western medicine

　　脑梗死后抑郁症是脑梗死后产生的一种包括多种精神和躯体症状的复杂的情感性精神障碍性疾病。2004-11—2007-05，我们采用养血益脑饮联合盐酸氟西汀胶囊治疗脑梗死后抑郁症68例，并与单用盐酸氟西汀胶囊治疗54例对照观察。现报告如下。

　　1  资料与方法

　　1.1  一般资料 

　　122例均为北京市门头沟区医院中医科门诊患者，采用随机数字表法分为2组。治疗组68例，男38例,女30例；平均年龄（66.53±6.52）岁；病程（10.46±5.78）个月。对照组54例,男29例,女25例；平均年龄（65.86±5.97）岁；病程（9.89±5.64）个月。2组一般资料比较差异无统计学意义（P>

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