|
脑损伤大鼠胫骨骨痂中降钙素基因相关肽的改变 |
| |
cal staining.Results Concentration of ALP in serum of brain injury group were significantly higher than those in tibial fracture group at 3 d and 7 d (P＜0.01).The area of callus in brain injury group was larger than in tibial fracture group at 14 d and 21 d.There were a quantity of fibrous callus and cartilaginous callus formation and more CGRP immunoreactive nerve fibers in callus at early stage after brain injury.Strong immunoreactivity of CGRP was found in osteofenitor cells，chondroblasts，which proliferated in thickened endoperiosteal and amidst callus at 3 d and 7 d in brain injury group.The tibial fracture recovers rapidly and CGRP in the callus expresses highly after brain injury.Conclusion CGRP have significant effect on bone fracture healing，the expression of CGRP showed different expression in different period of fracture healing，CGRP increase in callous with brain injured rats.this fact indicated that CGRP were involved in fracture healing.
Key words：brain injury；tibial fracture；CGRP；rat
临床和实验观察表明，骨的生长及修复受神经因素的影响［1］。众多研究表明，感觉和自主神经纤维分布在骨及骨膜上，其释放的神经肽的增加在骨痂形成的早期即可以测到，神经肽在骨折愈合重建中发挥重要作用。本实验采用免疫组织化学技术和大鼠脑损伤加胫骨骨折的动物模型，研究不同时间点胫骨骨痂中降钙素基因相关肽(calcitonin gener上一页 [1] [2] [3] [4] [5] [6] 下一页
上一个医学论文： 跟骨骨折的钢板内固定治疗
下一个医学论文： 踝关节骨折的分型和治疗进展
|
|
|
|
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 中医论文 >> 正文