老年心力衰竭患者白细胞介素4 6 8 10水平的临床研究

【摘要】  目的 探讨老年心力衰竭患者IL-4、IL-6、IL-8、IL-10 的变化及其相关性。方法 采用ELISA法，测定100例不同病因和心功能的心力衰竭患者和32例心功能正常对照组受试者血清IL-4、IL-6、IL-8、IL-10浓度。结果 老年心力衰竭组与对照组比较，血清IL-6、IL-8明显增高，血清IL-10明显降低(P<0.01)，随心功能恶化，尤其在心功能Ⅳ级组变化最显著，血清IL-4水平在各心功能分级组无明显统计学差异;老年心力衰竭患者细胞因子的平衡变化： IL-10可以抑制细胞因子生成;老年心力衰竭患者细胞因子浓度与心功能参数的关系相关分析表明，HF患者血清IL-6、IL-8浓度与左室舒张末内径呈显著正相关(P<0.05)，与左室射血分数呈显著负相关(P<0.05)，血清IL-10浓度与左室舒张末内径呈显著负相关(P<0.05)，与左室射血分数呈显著正相关(P<0.05);不同病因引起的老年心力衰竭患者细胞因子水平比较由冠状动脉粥样硬化性心脏病、高血压性心脏病和风心病引起的HF患者，其血清IL-4、IL-6、IL-8、IL-10水平无差异;老年心力衰竭患者细胞因子间的相互关系，相关回归分析表明，IL-6与IL-10呈显著负相关。结论 老年心力衰竭患者细胞因子水平与心功能密切相关，与心力衰竭的病因无关。炎症细胞因子IL-4、IL-6、IL-8、IL-10形成网络，共同促进心力衰竭的发展及心功能的恶化。

【关键词】  心力衰竭;细胞因子;老年人

Changes of interleukin-4，interleukin-6，interleukin-8，interleukin-10 level in older patients with heart failure and their interactions

　　ZHANG Xin-wen，YANG Xian-bing，TUO Xi-ping.94826 Military Hospital，Shanghai 200433，China

　　[Abstract] Objective To evaluate the effect of interleukin-4，interleukin-6，interleukin-8，interleukin-10 in older adults with heart failure(HF).Methods Serum levels of interleukin-4，interleukin-6，interleukin-8，interleukin-10 were measured by enzyme-linked immunoassay in 100 older patients with HF with different pathogenesis and heart function and in 32 controls.Results Compared with control group，the level of serum interleukin-6 and interleukin-8，in the heart failure group are significantly increased(P<0.01)，the level of serum interleukin-10 are significantly decreased(P<0.05).Patients with HF showed significantly higher interleukin-6 and interleukin-8 and lower interleukin-10 concentrations.Patients with advanced HF(NYHA class Ⅳ)had the highest interleukin-6 and interleukin-8 and lowest interleukin-10 plasma levels;In the heart failure group，there was significant negative correlation(P<0.05)between level of serum interleukin-6 and interleukin-8 and LVEF(P<0.05)，and significant positive correlation interleukin-6

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