【摘要】 目的 观察钾通道开放剂烟酰胺对慢性肺源性心脏病患者血栓素B2(TXB2)和6酮前列腺素F1a(6KPGF1a)的影响，探讨其治疗肺源性心脏病的价值。方法 104例慢性肺源性心脏病患者随机分为观察组和对照组各57例，对照组采用常规治疗，观察组在常规治疗的基础上加用烟酰胺静脉滴注,均治疗14 d，观察2组患者临床血气分析变化，并采用放射免疫法测定2组患者治疗前后血浆TXB2、6KPGF1a水平。结果 观察组治疗后较治疗前血浆TXB2明显下降(P<0.05)，6KPGF1a明显升高(P<0.05)。治疗后观察组的TXB2明显低于对照组(P<0.05)，6KPGF1a明显高于对照组(P<0.05)。治疗后观察组的PaO2明显高于对照组(P<0.05)，PaCO2明显低于对照组(P<0.05)。结论 应用钾通道开放剂烟酰胺可改善TXB2/6K PGF1a平衡，对治疗肺源性心脏病具有一定价值。
【关键词】 烟酰胺;血栓素B2;6酮前列腺素F1a;慢性肺源性心脏病;肺动脉高压
Influence of potassium channel opener nicotinamide on thromboxane B2 and 6ketoprostaglandin Fla in patients with chronic pulmonary heart disease
YUAN Xiaomei，SUI Haojie,LI Jinlan
(1.Department of Respiratory Medicine,the First Affiliated Hospital of Xinxiang Medical College,Weihui 453100,China;2.Department of Nuclear Medicine,the First Affiliated Hospital of Xinxiang Medical College,Weihui,453100,China)
Abstract: Objective To observe the influence of potassium channel opener nicotinamide on thromboxane B2(TXB2) and 6ketoprostaglandin Fla(6KPGF1a) in patients with chronic pulmonary heart disease.Methods One hundred and four cases of chronic pulmonary heart disease were randomly divided into observation and control group(n=57).The conventional therapies were used in control group,based on these,the patients in observation group were given nicotinamide for 14 days.Clinical changes of blood gas analysis were observed and radioimmunoassay were used to measure the levels of TXB2 and 6KPGF1a in serum preand posttreatment in both grouops.Results Compared with pretreatment,the levels of TXB2 were lower,but 6KPGF1a were higher posttreatment in observation group(P<0.05).After treatment,the levels of TXB2 and PaCO2 in observation group were significantly lower than these in control group(P<0.05),but the level of 6KPGF1a and PaO2 in observation group were significantly higher than these in control group(P<0.05).Conclusio
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