来曲唑与克氯米芬用于多囊卵巢综合征促排卵疗效比较

【摘要】  　　目的 探讨来曲唑与克氯米芬用于多囊卵巢综合征（PCOS）引起无排卵性不孕妇女的促排卵效果及其对生殖激素的影响。方法 选择 PCOS患者41例，随机分为2组，来曲唑组（试验组)在月经周期第3～7 d口服来曲唑(LE)2.5 mg/d，克氯米芬组(对照组)在月经周期第3～7 d口服克氯米芬50 mg/d，开始超声监测卵泡发育，当最大卵泡平均直径≥18 mm时，肌肉注射绒毛膜促性腺激素(hCG) 10 000 IU诱发排卵，于hCG日取肘静脉血测定黄体生成素(LH)、雌二醇(E2)、睾酮(T)，并观察排卵率、妊娠率、子宫内膜厚度及生殖激素的变化。结果 来曲唑组的排卵率和周期妊娠率与克氯米芬组相似(P＞0.05)，来曲唑组单个优势卵泡的发生率和在hCG日子宫内膜的厚度均高于克氯米芬组(P＜0.05)，来曲唑组在hCG日血清LH、T水平与克氯米芬组间差异无统计学意义。结论 来曲唑用于多囊卵巢综合征引起无排卵性不孕妇女具有良好的排卵率和妊娠率。

【关键词】  多囊卵巢综合征 来曲唑 克氯米芬 促排卵

　　Comparison  of  the  effects  of  letrozole  and  clomiphene citrate  on  ovulation  induction  in  PCOS
   
　　Pan Weijun
   
　　Depertment of Obstetrics and Gynecology, Maanshan Maternity Child Health Hospital, Maanshan 243000,China
   
　　［Abstract］  Objective  To compare the effects of  letrozole  and clomiphene  citrate(CC) on ovulation induction in polycystis ovarian syndrome (PCOS) patients.Methods  Forty female patients with PCOS caused abnormal ovulation were divided into two groups randomly.One group was treated with letrozole(2.5 mg，qd×5 d) and the other group was treated with clomiphene(50mg，qd x5 d)．Ultrasound scan was per- formed to monitor follicle development．When the diameter of the biggest follicle reached 18 mm , 10 000 IU HCG was injected to trigger ovulation. The rates of ovulation,pregnancy and abortion ,the thickness of end- ometrium and reproductive hormone were compared between the two grou ps.Results  In letrozole group the ovulation rate and pregnancy rate percycle were similar to those of CC group (P>0.05),but the abortion rate was significantly decreased (P<0.05)．The thickness of endometrium on the day of HCG administration in the letrozole  group was much thicker than that in  CC group (P<0.05). Conclusion  Letrozole can attain good

[1] [2] [3] [4] [5] 下一页