【摘要】 目的： 观察银杏叶片联合布地奈德对哮喘儿童外周血辅助性T细胞(Th)亚群的影响。方法： 65例中、重度哮喘儿童随机分为两组：激素治疗组34例，单纯吸入布地奈德气雾剂治疗6个月;联合治疗组31例，吸入布地奈德气雾剂且同时口服银杏叶片6个月。测定治疗前后血浆中IL4，IFNγ水平，同时以20例健康儿童为正常对照组。结果： 两哮喘组治疗前、后血浆IFNγ水平均低于正常对照组(P<0.01)，治疗后IFNγ水平均高于治疗前(P<0.01)，两哮喘组治疗后IFNγ水平无明显差异(P>0.05);两哮喘组治疗前、后血浆IL4和IL4/IFNγ均显著高于正常对照组(P<0.01或P<0.05);治疗后两组IL4和IL4/IFNγ均下降(P<0.01)，且联合治疗组低于激素治疗组(P<0.01)。结论： 银杏叶片与布地奈德具有协同作用，联合应用更有利于纠正失衡的Th亚群。
【关键词】 哮喘; 白细胞介素4; γ干扰素; T淋巴细胞亚群; 银杏叶
Effects of Ginkgo biloba tablets plus aerosol budesonide on T helper cell subsets in children with asthma
XIN Yue， L Jinquan， L Jianping, TANG Yan, ZHANG Xiaoming
(Department of Pediatrics，the Affiliated Hospital of Jiangsu University， Zhenjiang Jiangsu 212001, China)
[Abstract]Objective: To observe the effects of Ginkgo biloba tablets plus aerosol budesonide on T helper cell subsets in children with asthma.Methods： Sixtyfive children with moderate or severe asthma were randomizedly divided into two asthma groups: 34 cases were adopted as budesonide group, which were treated with inhalation of budesonide alone for 6 months，and other 31 cases were adopted as the combined therapy group, which were treated with inhalation of budesonide and oral Ginkgo biloba tablets also for 6 months. The normal control group was 20 healthy children. ELISA was used to determine the serum concentrations of IFNγ and IL4. Results： The serum concentrate ration of IFNγ before and after the treatment in the combined therapy group and the budesonide group was decreased than that of normal group(P<0.01), and in the two asthma groups, the serum concentrate ration of IFNγ after treatment was increased than that of before treatment(P<0.01), but the serum IFNγ in the two asthma groups after treatment had no significant difference(P>0.05). The IL4 and IL4/IFNγ levels before and after treatment in the combined therapy group and the budesonide group were higher than th
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