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¡¡¡¡Research of atorvastatin calcium in the treatment for antiphospholipid syndrome in patients aged over 80 HUANG Fang, ZHANG Yuan, LIU Yongª²hua, WAN Wenª²hui, QIAN Xiaoª²ming. The First Department of Geriatrics, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, China

¡¡¡¡¡¾Abstract¡¿¡¡Objective To observe the clinical features of antiphospholipid syndrome (APS) in patients aged over 80, and to approach the effects of statins on preventing and treating repeated relapse cardia and cerebral vessels ischemic events. Methods The clinical data of 15 patients with repeated relapse cardia and cerebral vessels ischemic events were retrospectively analyzed. The patients received atorvastatin calcium 20 mg per night on the basis of routine antiplatelet and anticoagulation treatment. The changes of the levels of antiª²phospholipid antibody¬ðs tite (aCL),oxidized low density lipoprotein (Oxª²LDL), blood fat,blood plate, and the occurrance of cardia and cerebral vessels ischemic events were observed. Results The levels of total cholesterol (TC), triglyceride (TG), lowª²density lipoprotein cholesterol (LDLª²C), highª²density lipoprotein cholesterol (HDLª²C) of the patients aged over 80 were normal or partially low. But the levels of Oxª²LDL were high. After treatment the aCL titer was decreased or descended to negative, and Oxª²LDL descended to normal level. The cervical artery plaques were stable. After 12 months¬ð followª²up, the occurrence rate of cardia and cerebral vessels isch

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