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磷酸肌酸对早期舒张功能障碍的疗效 |
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tension, hypertrophic cardiomyopathy and aortic stenosis, are more likely to suffer diastolic heart failure because chronically heavy pressure load may induce left ventricular hypertrophy and ventricular filling;(4)When myocardium is under ischemic state, because lack of oxygen, fatty acid oxidation decrease,oxidative phosphorylation of mitochondria block, ATP production in cells decrease and anaerobic glycolysis increase,so cause accumulation of myocardial metabolism waste, acidosis, cell structure and function change, more Ca2+ enter the cells, intracellular Ca2+ overload becomes more serious,thereby induce left ventricular diastolic dysfunction.
CP is an endogenous substance. It plays an important role in myocardial energy metabolism. Its molecule contains high-energy nitrogen-phosphorus bonds, which generate energy substance ATP of myocardial cells’ activity through Lohmann reaction(CP+ADP←→Cr+ATP). It has been proved that the CPK is key substance of that reaction, it contains 4 types of isozyme, which exist in the end gap of mitochondria, serolemma, sarcoplasmic reticulum and myofibril. They play an important role in cellular energy load, insurance of energy opening ion channel, and slipping of actin and myoglobulin, Hearse study showed that intracellular CP level will decline, then followed by ATP level decline, moreover CP level is lower than ATP level, when myocardial ischemia occurs. Also, it has been proved that exogenous CP is not only involved in energy metabolism of myocardial cells, but also has membrane protective effect.
CP can reduce calcium overload of myocardial cells, thereby diastolic function is improved. This medicine can deeply reach respective locus in cells, participate in Lohmann reaction, generate ATP, supply energy and therefore increase the activity of membrane pump, stable membrane phospholipids, reduce membrane damage and lower the calcium influx. Look from molecular level, the lack of O2 will result in the reuptake 上一页 [1] [2] [3] [4] [5] [6] 下一页
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