磷酸肌酸对早期舒张功能障碍的疗效

　　CP groupControl group

　　Before

　　treatment

　　(Cases)

　　After treatment (Cases)

　　Marked

　　effective (%)Effective

　　(%)Ineffec-

　　tive (%)

　　Before

　　treatment

　　(Cases)

　　After treatment (Cases)

　　Marked

　　effective (%)Effective

　　(%)Ineffec-

　　tive (%)

　　E/A10989(81.65)△△20(8.35)0293(10.34)25(86.21)1(3.45)

　　Ea/Aa10991(83.49)△△18(16.51)0294(13.79)23(79.31)2(6.9)

　　E/Ea9891(92.86)△△7(7.14)0253(12)20(80)2(8)

　　Note: Compared with control group △△P<0.01.

　　Discussion:

　　The morbidity rate of diastolic heart failure has been sharply rising followed by increasing morbidity rate of some other disease such as ageing of population, hypertension, diabetes, obesity, and coronary heart disease. Early intervention of primary disease and diastolic dysfunction is the key to prevent diastolic heart failure. The mechanisms of diastolic dysfunction were：(1)When the patients suffer from myocardial ischemia or myocardial hypertrophy, their calcium overload in the heart muscle is more likely to happen. All factors making trouble in process of myocardial cells reuptake or discharging the Ca2+ can cause calcium overload and diastolic dysfunction. These factors include ability and velocity of sarcopasmic reticulum (SR) reuptake Ca2+ decline, phosphorylation mediated by cAMP decline and phosphorylation of phospholamban decline etc.;(2)Stiffness of myocardial cells: Myocardial stiffness is directly related with the condition of myocardial cells. The stiffness of myocardial cells progressively increasing is an underlying cause diastolic dysfunction. When quantity and expression of connectin have been damaged, elasticity of myocardial cells will be reduce, and stiffness will be increase，afterwards, diastolic dysfunction appears; (3)The patients suffer from hyper

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