磷酸肌酸对早期舒张功能障碍的疗效

　　(3)Evaluation standards:

　　①Diagnosis standards:Mild diastolic dysfunction: E/A <1, Ea/Aa<1, 8< E/Ea<15.

　　Moderate diastolic dysfunction: E/A>1(pseudo-normalization), Ea/Aa<1, 8

　　②Therapeutic effect standards:

　　Marked effective: original E/A<1 to >1, E/A pseudo-normalization to normal level, Ea/Aa>1, E/Ea<8; Effective:E/A, Ea/Aa ratio is much improved but still not back to normal, E/Ea is better than before but still more than eight; No effect: no obvious change for all indexes

　　2. Result:

　　After treatment, there was obvious improvement in symptoms and signs. The marked effective rate of symptoms and signs in CP group was significantly higher than that of control group (96.2% vs. 57.1%, P<0.01). Compared with before treatment, there was no significant abnormal change on tests of liver function, kidney function and serum after treatment. Please see table 1, table 2, picture 1 and picture 2.

　　Table 1Comparison of clinical symptoms and signs before and after treatment between creatine phosphate (CP) group and routine treatment control (control)group

　　CP groupControl group

　　CasesMarked

　　effective

　　(%)Effective

　　(%)Ineff-

　　ective (%)

　　CasesMarked

　　effective

　　(%)Effective

　　(%)Ineff-

　　ective (%)

　　Palpitation7474 (100)00199(47.36)10(52.63)0

　　Chest distress6565 (100)00106(60.00)4(40.00)0

　　Insomnia 7165 (91.55)6 (8.45)0237(30.43)14(60.87)2(8.70)

　　Shortness of breath on exertion6363 (100)00106(60.00)4(40.00)0

　　Tiredness9595 (100)002817(60.71)10(35.72)1(3.57)

　　Moist rales on base of lung10898 (90.74)10 (9.26)02819(67.88)9(32.12)0

　　Bilateral Lower limb edema10898 (90.74)10 (9.26)02619(73.08)7(26.92)0

　　Mean96.2△△3.8057.141.21.7

　　Note: Compared with control group △△P<0.01.

　　Table 2Comparison of diastoli

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