磷酸肌酸对早期舒张功能障碍的疗效

　　1.2Method:

　　All patients received routine treatment. The patients of CP group received CP(Neoton, Italian pharmaceutical company of Alfa Wassermann)intravenous drip and routine treatment, the method was CP 2g+5%glucose or 0.9% sodium chloride 100ml, iv. drip, for patients with mild diastolic dysfunction was 1time/d, patients with moderate diastolic dysfunction was 2 times/d, duration was 7~14 days.

　　1.3Curative Effective Standards:

　　Symptoms: Palpitation, Short of Breath, , Tiredness.

　　Standards: Marked effective-the symptoms totally disappeared; Effective-the symptoms had been relieved; Ineffective-no any change

　　Signs: Pulmonary rales and bilateral lower limb edema

　　Standards: Marked effective-pulmonary rales and bilateral lower limb edema disappeared; Effective-pulmonary rales and bilateral lower limb edema improved; Ineffective-no any change

　　Others:Blood pressure, heart rhythm, heart rate, early stage of kidney damage, routine blood test, liver function and ECG

　　Cardiac function:

　　(1)The equipment used: color Doppler GE V7 and Siemens S2000

　　(2)Measured method: The E(transmitral peak early diastolic velocity) / A(transmitral peak late diastolic velocity)ratio was measured by Doppler ultrasound blood flow technique.The sample volume was placed at the tip of the mitral valve leaflets in the four-chamber apical view. The Ea(peak early diastolic velocity of mitral annulus)/ Aa(peak late diastolic velocity of mitral annulus)ratio was measured by Doppler ultrasound tissue technique:the sample volume was placed in mitral annulus cross. The E / Ea ratio (left ventricular diastolic function indexes, more than 15 was positive for diastolic heart failure diagnosis, less than 8 was normal for diastolic function, ranging from 8 to 15 was diastolic dysfunction) w

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