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罗库溴铵量效关系两种测定方法的比较 |
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陈锡明 杭燕南 孙大金
摘要 目的：分别选用单次法和二次累积法测定罗库溴铵的剂量和效应的关系。方法：34例，ASAⅠ～Ⅱ级，年龄23～65岁，施行择期腹部或颅脑手术的患者，分为单次法组和累积法组。单次法24例，分为4个亚组，分别接受罗库溴铵150、200、250和300μg／kg。累积法10例，分为2个亚组，首次剂量分别接受罗库溴铵150或200μg/kg，阻滞达最大时追加第二次剂量，使阻滞达90%左右。采用对数剂量和概率单位转换和直线回归计算量效应曲线。结果：单次法求得的ED50和ED95分别193.6±69.1和367.2±72.75μg/kg，累积法分别为213.0±55.1和418.5±61.7μg/kg。两种方法求得的ED50、ED95、曲线斜率和截距均无显著性差异。结论：用累积法测定罗库溴铵的量效应关系，可以省时、省工，而结果同样可靠。
关键词 罗库溴铵 累积法 剂量效应关系，药物
Comparison of cumulative and single dose techniques for determining dose-response relationship of rocuronium Chen Ximing，Hang Yannan，Sun Dajin．Department of Anesthesia，RenJi Hospital，Shanghai Second Medical University，Shanghai 200001
Abstract Objective：To compare cumulative dose technique with single dose technique for determining dose-response relationship of rocuronium during balanced anesthesia．Method：Thirty-four ASA grade Ⅰ-Ⅱ patients，aged 23-65 years，undergoing elective surgery，were randomly allocated to single dose group（n＝24） or cumulative dose group（n＝10）．Single dose group was further divided into 4 subgroups receiving 150，200，250 or 300μg／kg of rocuronium respectively．In cumulative dose group，the initial dose of 150 or 200 μg／kg rocuronium was followed by a second dose determined individually to produce about 90％ neuromuscular block．The ulnar nerve was stimulated at the wrist to measure the accelography of thumb adduction．The relationship between probit-transformed depression of first twitch height of TOF and the logarithm dose of rocuronium was analysed using linear regression．Result：ED50 and ED95 of rocuronium were 193．6±69．1 and 367．2±72．7μg／kg respectively in single dose group，and 213．0±55．1 and 418．5±61．7μg／kg respectively in cumulative dose group．No statistically significant differences were found in the slope，intercept，ED50 and ED95 values between two groups．Conclusion：The two-dose cumulative technique can be used as [1] [2] [3] 下一页
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