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经肝动脉化疗栓塞后TGF |
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刘谨文 易继林
［摘要］ 目的 探讨 经肝动脉化疗栓塞后TGF-β1、TGF-α在肝癌细胞凋亡中的作用。方法 应用免疫组织化学方法检测19例未经肝动脉化疗栓塞(TACE)和36例经TACE治疗的肝 癌组织中TGF-β1、TGF-α的表达，采用ISEL法检测肝癌细胞凋亡。结果 经TACE治疗和未经TACE治疗的肝癌组织中TGF-β1表达率分别为86.11%和36.84%；T GF-α表达率分别为36.11%和84.21%；肝癌细胞凋亡指数分别为0.0088和0.1901。结论 经TACE治疗后TGF-β1表达增强，促进了肝癌细胞凋亡。TGF- α主要与肝癌细胞增殖有关，其表达减弱亦可能促进了肝癌细胞凋亡。
［关键词］ 凋亡； 肝癌； TGF-β1； TGF-α； 化疗栓塞
［中图分类号］ R735.7 ［文献标识码］ A ［文章编号］ 1005-6483 (2000)06-0352-02
The effect of TGF-β1 and TGF-α on hepatic apopotosis in hepat ocelluler carcinoma after transcather arterial chemoembolization
LIU Jinwen,YI Jilin
（Department of Surgery, Tongji Hospital,Tongji M edical University,Wuhan 430030，China）
［Abstract］ Objective To investigate the effect of TGF -β1 and TGF-α on hepatic apoptosis in hepatocelluler carcinoma (HCC) after t ranscather arterial chemoembolization (TACE).Methods The sp ecimens were surgically obtained from 36 patients who had been treated by TACE ( TACE group) and 19 patients without any treatments (no-TACE group). Expression of TGF-β1 and TGF-α in HCC tissues was detected by immunohistochemical met hod. Apoptosis was detected by ISEL method.Results Expressi on rates of TGF-β1 in HCC tissues of TACE group and no-TACE group were 86.1 1% and 36.84% respectively.expression rates of TGF-α in HCC tissues of TACE gr oup and on-TACE group were 0.0088 and 0.1901 respectively.Conclusions After TACE, the expression of TGF-β1 was enhanced to accelerate the hepatic apoptosis in HCC.TGF-α was mainly related to the cell proliferati on in HCC.That the expression of TGF-α was inhibited after TACE might accelera te the hepatic apoptosis of HCC.
［Key words］ Apoptosis； Hepatocelluler carcinoma; TGF-β1； TGF-α; Chemoembolization
经肝动脉化疗栓塞(transcather arterial chemo-embolization,TAC E)是非 手术治疗原发性肝[1] [2] 下一页
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