乙肝型炎肝硬化患者肝移植后近期肝肾脾功能的变化

　　【摘要】目的：观察乙型肝炎肝硬化患者肝移植前后肝、肾及脾功能的变化。方法：行肝移植治疗的11例乙型肝炎肝硬化患者，移植前后检测肝、肾及脾功能，分析其变化。结果:凝血酶原时间:术后2d已显著低于术前,术后5d正常;球蛋白:术后1d正常，2d显著低于术前;肌酐：术后1d显著高于术前，7d恢复正常;血小板：术后3d显著下降，14d显著高于术前，21d正常。肾功能不全发生率72.3%,但均能恢复。结论：肝移植后，凝血酶原时间和球蛋白恢复正常，肌酐上升后短时间内可恢复正常，血小板下降后又恢复正常。

　　【关键词】肝移植?肝炎，乙型?肝硬化?球蛋白类?凝血酶类?胆酯酶类?白蛋白类?胆硷酯酶类?胆固醇?肌酸酐

　　Early changes of the hepatic renal and splenic function in hepatitis B liver cirrhosis patient after liver transplantation

　　YU Jianguang,LIU Junmao,YI Yongxiang,SHA Li

　　Department of Surgery,Nanjing Second Hospital (Nanjing 21003,China)

　　【ABSTRACT】Objective:To research the changes of the hepatic,renal and splenic function in hepatitis B liver cirrhosis patient after liver transplantation.Methods:Liver transplantation is performed for 11 cases suffered from hepatitis B liver cirrhosis,the hepatic,renal and splenic functions are observed,their changes are analysed.Results:Time of thrombin is lower significantly after operated 3 days than before operation and get to normal after operated 5 days;globin get to normal after operated 1 day and is lower significantly after operated 2days than before operated;Cr is higher significantly after operated 2 days than before operated and get to normal after operated 7 days;blood platelet is lower significantly after operated 3 days than before operated and higher significantly after operated 14 days than before operated,get to normal after operated 21 days.Conclusion:After liver transplantation,time of thrombin and globin get to normal,Cr rises up at the first and get to normal then,blood platelet decreases at the first and get to normal then.

　　【KEY WORDS】Liver transplantation?Hepatitis B?Liver cirrhosis?Globulins?Prothrombin?Albumins?Cholinesterases?Cholesterol Creatinine

　　肝移植是治疗乙型肝炎所致的终末期肝硬化有效方法，为了掌握该类患者施行肝移植后重要功能变化情况，我科对11例乙型肝炎所致的终末期肝硬化患者施行了同种异体原位肝移植，肝、肾及脾功能的变化情况进行总结。

　　1 资料和方法

　　1.1 临床资料男8例，女3例，年龄28~62岁，平均45.2岁。其中7例为终末期乙型肝炎肝硬化，4例为乙型肝炎肝硬化并发

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