【摘要】 目的 探讨p57kip2蛋白、p21cip1蛋白在人脑胶质瘤中的表达情况及其临床意义。方法 采用免疫组织化学SP法检测p57kip2、p21cip1在55例人脑胶质瘤和10例正常脑组织中的表达。结果 在55例胶质瘤中，p57kip2蛋白阳性率为38.2%(21/55)，显著低于正常脑组织的80%(8/10)(P= 0.036)。p57kip2蛋白表达在低度恶性(Ⅰ-Ⅱ级)组显著高于高度恶性(Ⅲ-Ⅳ级)组(P=0.029)，生存时间≥2年组显著高于<2年组(P=0.032)。脑胶质瘤中p21cip1蛋白阳性率为60.0%(33/55)，与正常脑组织的90.0%(9/10)相比，差异无统计学意义(P=0.143)。p21cip1蛋白表达在高度恶性(Ⅲ-Ⅳ级)组显著低于低度恶性(Ⅰ-Ⅱ级)组(P=0.047)，生存时间<2年组显著低于≥2年组(P=0.002)。p57kip2蛋白的表达与p21cip1蛋白的表达存在正相关(rs=0.354，P=0.008)。结论 p57kip2蛋白和p21cip1蛋白在脑胶质瘤中存在异常表达，p57kip2蛋白和p21cip1蛋白的表达程度与脑胶质瘤的分化程度、预后相关。
【关键词】 p57kip2蛋白 p21cip1蛋白 胶质瘤 免疫组织化学
Expressions of p57kip2 and p21cip1 in humanglioma and their clinical significance
Yang Tao, Zhang Xi, Zhou Le, Qu Jianqiang
(1. Department of Neurosurgery, the Second Affiliated Hospital, Medical School of
Xian Jiaotong University, Xian 710004; 2. Department of Neurosurgery,Affiliated Hospital, Ankang Vocational and Technical College, Ankang 725000, China)
ABSTRACT: Objective To explore the expressions of p57kip2 and p21cip1 in human gliomas and their clinical significance. Methods P57kip2 and p21cip1 were detected by SP immunohistochemical technique in 55 human glioma and 10 normal brain tissues. Results Expression rate of p57kip2 protein in human glioma was 38.2%(21/55), which was significantly lower than that in normal brain tissues 80%(8/10) (P=0.036). P57kip2 expression in low malignance group (Ⅰ-Ⅱ grade) was significantly higher than that in high malignance group (Ⅲ-Ⅳ grade) (P=0.029) and in survival time ≥2 years group was significantly higher than that in <2 years group (P=0.032). Expression rate of p21cip1 protein in human glioma was 60.0 % (33/55), not significantly lower than that in normal brain tissues 90.0% (9/10) (P=0.143). P21cip1 expression in high malignance group (Ⅲ-Ⅳ grade) was significantly lower than that in low malignance group (Ⅰ-Ⅱ grade) (P=0.047) and in survival time<2 years group was significantly lower than th
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