【摘要】 目的 以5%甘露醇冲洗液建立犬经尿道电切综合征(TURS)模型，探讨TURS对心功能影响。方法 家犬8只，以100 mL/min速度静脉输入5%甘露醇冲洗液3 000 mL，建立犬TURS模型;于输液前和输液后10、20、30、60 min，测定心功能，血清钾、钠、氯浓度，心肌酶谱，心电图，并进行病理观察。结果 心率、左室舒张期末内径、收缩期末内径在30 min时增加(P值均<0.05)，收缩压、舒张压、脉压和射血分数30 min时降低(P值均<0.05)。血清天冬氨酸转氨酶、乳酸脱氢酶、肌酸激酶和肌酸激酶同工酶在60 min时的变化无统计学意义(P>0.05)。TURS时心电图可有心律不齐和心肌缺血改变。病理观察示心肌纤维间充血和局部变性，肺脏水肿。结论 TURS可引起心功能改变，并造成心肌损伤。发生TURS时心率和血压的改变出现较早，应足够重视，并及时的检测血清离子。
【关键词】 经尿道电切综合征 水中毒 心功能 心肌酶谱 犬
Establishment of the Transurethral Prostate Resection Syndrome Model and the Evaluation on Cardiac Function
FENG Yanhong，JIANG Huamao，ZHANG Chunyang， ZHANG Datian，LIU Yan
Department of Ultrasound, the First Affiliated Hospital of Liaoning Medical University，Jinzhou 121001 China
Abstract : Objective To establish the transurethral prostate resection syndrome model in dogs and probe into the effects on cardiac function of the models of TURS. Methods We established animal models in eight dogs by intravenous injections of 3 000 mL 5% Mannitol at 100 mL/min. Cardiac function and electrocardiogram were examined before and after 10,20,30 and 60 minutes when serum dielectrics, myocardial enzymes were measured. Samples of the cardiac muscle and lung were taken out 60 minutes after the drug administration and were observed the histological changes. Results Heart rate, left ventricular end-diastolic dimension and left ventricular end-systolic dimension were increased 30 minutes after administration(P<0.05), systolic blood pressure, diastolic blood pressure pulse pressure and ejection fraction and shortening fraction but decreased in 30 minutes(P<0.01). The serum sodium, potassium and chloride levels were decreased at any time points, but the changes of myocardial enzymes were insignificantly in 60 minutes after administration(P>0.05). There were such changes as anisorhythmia, myocardial ischemia in electrocardiogram. Pathological examination revealed hyperaemia among myocardial fiber
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