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肿瘤细胞周期中Cyclin E的失调节

the SCFFbw7 ubiquitin ligase. Science,2001,294:173~177.

  12 Strohmaier H, Spruck CH, Kaiser P, et al. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature,2001,413:316~322.

  13 Susanna ER, Spruck CH. Spruck R, et al. Mutation of hCDC4 Leads to Cell Cycle Deregulation of Cyclin E in cancer. Cancer Rescarch,2004, 64: 795.

  14 Mao JH, Losada JP, Wu D, et al. Fbxw7/Cdc4 is a p53-dependent haploinsufficient tumour suppressor gene. Nature, 2004,432:775~779.

  15 Reed SE, Mendez J, Tedesco D, et al. Deregulation of cyclin E in human cells interferes with prereplication complex assembly. J Cell Biol,2004,165:789~800.

  16 Woo RA, Poon RY. Cyclin-dependent kinases and Sphase Control in Mammalian Cells. Cell Cycle,2003,2:316~324.
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