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尿纤维连接蛋白在诊断膀胱移行细胞癌中的应用价值 |
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e urinary cytology. Results：The urinary Fn and Fn/Cr ratios were significantly higher in bladder cancer(Fn 583.4±302.5μg/L,Fn/Cr 149.5±93.3mg/mol)than in other urogenital diseases(Fn 209.3±125.0μg/L,Fn/Cr 52.4±36.2 mg/mol)and the healthy subjects(Fn 134.3±83.6μg/L,Fn/Cr38.2±22.7mg/mol)(P<0.01,P<0.05). The sensitivity and specificity of urinary Fn were 78.2% and 76.2%,respectively in the patients with bladder cancer,while urinary Fn/Cr ratio were 81.8% and 79.4% respectively. Moreover,urinary Fn and Fn/Cr ratio had obvious discrepancy among tumor grades and stages(P<0.05，P<0.05). Otherwise,Sensitivity and specificity of the urinary Fn/Cr were not higher than that of the other urinary tumor markers cited in the literature. Conclusion：Urinary Fn and Fn/Cr ratios have significant diagnostic value in the patients with bladder cancer. Urinary Fn is claimed to be a potential role in the diagnosis and prognosis of bladder cancer. Obvious relationship between urinary Fn and the stages or grades has been noted. Determining urinary Fn values may give an idea about the invasive potential of the tumor and may estimate the prognosis. However,as with the other urinary tumor markers,the test performance was not sufficient to replace cystoscopy. The optimal cutoff was established at 250μg/L for urinary Fn and 62mg/mol for Fn/Cr.
【KEY WORDS】 Urinary fibronectin; Urinary fibronectin /urinary creatin value; Bladder transitional cell cancer
2007年10月凌海滨等：尿纤维连接蛋白在诊断膀胱移行细胞癌中的应用价值第5期2007年10月河北北方学院学报(医学版)第5期 目前膀胱镜检查及可疑病变处活检仍是膀胱癌诊断和随访的金标准。为寻求无创、简便、准确的诊断方法，研究者们不断地探索。近年来，通过检测尿液中相关的肿瘤标记物作为膀胱肿瘤诊断的方法得到广泛研究，多种无创、简便的分子生物学指标应用于膀胱肿瘤患者尿液的检测，包括核基质蛋白22(NMP22)、膀胱肿瘤抗原(BTA)、存活素(SV)、透明质酸(HA)及透明质酸酶(HAase)、细胞角蛋白(CK)等，在隐匿性和复发性膀胱肿瘤早期诊断和术后随访研究中，取得了令人鼓舞的成果[1～4]。本课题对尿纤维连接蛋白在诊断膀胱癌中的临床价值进行探讨，可望为该病患者的早期诊断及筛选提供新的手段。
1 资料和方法
1.1 一般资料
1.1.1 膀胱癌组 55例，均来自我院2005.11～2006.4月泌尿外科住院患者，所有病例均行膀胱镜检查，并经病理切片证实为膀胱移行上皮细胞癌;其中男40例，女15例;年龄33～84岁，平均56.7岁。根据国际抗癌协会(UICC)及美国癌症分期委员会(AJ 上一页 [1] [2] [3] [4] [5] [6] 下一页
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