【摘要】 [背景]探讨原发性胆囊癌的临床病理特点.[病例报告]回顾性分析25例胆囊癌手术标本的病理资料，结果见浸润型为16例，乳头突起型为6例，溃疡坏死型为3例;低分化腺癌为12例，高分化腺癌为6例，乳头状腺癌为4例，鳞状细胞癌为2例，黏液腺癌为1例.[讨论]胆囊癌主要临床表现与慢性胆囊炎相似，术前诊断较困难，B型超声波检查是胆囊癌诊断最常用且可靠的手段，提高胆囊癌患者生存率的关键仍是早期诊断及早期治疗.
【关键词】 胆囊肿瘤;病理分型;胆囊炎
Pathological analysis of 25 cases of primary carcinoma of gallbladder
ZHANG Weihua, CHEN Qiuyan, HUANG Yong, YANG Kangjuan*
(Department of Cell Biology and Medical Genetics, Yanbian University College of Basic Medicine, Yanji 133000, Jilin, China)
ABSTRACT:BACKGROUNDTo investigate the clinicopathological features of primary carcinoma of the gallbladder (PCG).CASE REPORTSThe pathological data of 25 cases with carcinoma of gallbladder were retrospectively analyzed. The results showed that 16 cases were of infiltrative type, 6 cases of papillary type and 3 cases of necrotizing ulcerative type; the histological types was that 12 cases were of poorly differentiated adenocarcinoma, 6 cases of well differentiated adenocarcinoma, 4 cases of papillary adenocarcionoma, 2 cases of sqnamouscell carcinoma and 1 case of mucinous adenocarcinoma.DISCUSSIONThe clinical manifestation of gallbladder carcinoma is similar to the chronic cholecystitis, and the PCG is some difficult for preoperative diagnosis. The B ultrasound examination is the more frequently used and reliable method for diagnosis the PCG, and at present, the early diagnosis and treatment of gallbladder carcinoma is the key to raise survival rate.
Key words:gallbladder neoplasms;pathological analysis;cholecystitis
原发性胆囊癌是胆道恶性肿瘤之一，占所有肿瘤的1%左右，居消化道肿瘤第6位，常发生于50～70岁的老年女性.因原发性胆囊癌的症状及体征与胆囊炎和胆石症相似，容易混淆，大部分胆囊癌是在手术时被发现，多已属晚期[1].本观察选择原发性胆囊癌25例，并对其临床病理特点进行了分析.
1 临床资料
1.1 一般资料 选择吉林省四平市中心人民医院在1998年2月至2008年2月10年间实施的胆囊癌手术标本25例，均经病理学检查确诊.所有标本均采用40mL/L甲醛固定，石蜡包埋，切片，行HE染色，在光学显微镜下进行观察.本组25例中男性为4例，女性为21例;年龄最大者为76岁，最小者为44岁，其中44，45岁者为3例，56～60岁为8例，61～65岁为8例，66～70岁为5例，75岁以上为1例，平均为60岁;主要临床表现为右上腹疼痛，出现黄疸者为11例，恶心呕吐者为11例，畏寒发热为4例，上腹部出
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