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大鼠肢体缺血再灌注早期血栓前状态的研究 |
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【摘要】 目的 探讨大鼠急性下肢缺血再灌注早期血栓的形成情况。方法 将大鼠随机分为假手术组、下肢缺血再灌注组两组。夹闭大鼠股动脉并用张力带绑扎下肢，建立急性下肢缺血再灌注大鼠模型。观察急性下肢缺血再灌注大鼠血小板膜糖蛋白GPⅡb/Ⅲa和血管内皮细胞血栓调节蛋白(thrombomoclulin，TM)的表达。结果 缺血再灌注组大鼠血小板膜糖蛋白GPⅡb/Ⅲa表达高于假手术组(P＜0.05)；缺血再灌注组大鼠血管内皮TM表达低于假手术组(P＜0.05)。结论 急性下肢缺血再灌注可能导致大鼠血栓前状态的形成。
【关键词】 肢体缺血再灌注；血栓前状态；血小板膜糖蛋白；血栓调节蛋白
Prethrombotic State in Rats after Ischemiareperfusion of Limb and it′s Intervention Study
YANG Min，MA Ping，XU Wenhui，et al
(Department of Anesthesia，the 2nd Hospital of Shanxi Medical University，Taiyuan 030001，China)
Abstract：Objective To investigate the emerge condition of thromb in rats after ischemiareperfusion of limb.Methods The rats were randomly divided into 2 groups：sham operation group(N group)；the hind limb ischemia reperfusion group (IR group).An animal model of acute hind limb ischemiareperfusion was developed by clamping femoral artery and banding hind limb of rats.Changes in the expression of GPⅡb/Ⅲa of platelet membrane and TM of vascular endothelial cell in rats after ischemiareperfusion of limb were observed.Results The expression of GPⅡb/Ⅲa of platelet membrane in the IR group was significantly higher than that of the N group (P＜0.05).The expression of TM&[1] [2] [3] [4] [5] [6] [7] 下一页
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