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抗生素应用与婴幼儿慢性腹泻病的关系 |
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许能锋 吴斌 陈素清
摘要 目的 探讨抗生素应用与婴幼儿慢性腹泻病的关系。方法 于1997 年4～10月，以福建医科大学附属第一医院儿科1987年1月～1996年12月住院治疗的32例慢性腹泻患儿为病例组，分别以急性腹泻患儿、急性呼吸道感染患儿为对照组进行了1∶4配比和成组匹配的病例对照研究。结果 以非条件logistic多元回归模型有效控制其他因素的混杂偏倚后，无论是以急性腹泻患儿为对照，还是以急性呼吸道感染患儿为对照，急性期无选择地使用抗生素都是慢性腹泻病的主要危险因素，其OR值分别为5.61(OR 95%CI 1.15～27.36)和16.92(OR 95%CI 2.67～107.32)，而且趋势χ2分析发现，急性期所用抗生素种类越多，OR值越大。结论 急性期无选择地使用抗生素是慢性腹泻病的重要危险因素。发病早期加强病原学诊断、合理使用抗生素，对减少婴幼儿急性腹泻慢性化有十分重要的意义。
关键词 腹泻 抗生素类 病例对照研究
Relationship between Use of Antibiotics and Chronic Diarrhoea in Infants and Young Children
XU Nengfeng*, WU Bin, CHEN Suqing.
*Department of Epidemiology, Fujian Medical University, Fuzhou 350004
Abstract Objective To study the relationship between use of antibiotics and chronic diarrhea in infants and young children. Methods A matched case-control study was carried out in Fuzhou City, Fujian Province during April to October 1997, with a total of 32 cases, (aged 1-19 months), with chronic diarrhea (with a length>2 months), and 128 cases of acute diarrhea (as control group Ⅰ) and 94 cases of acute respiratory tract infection (as control group Ⅱ), from the Department of Pediatrics, the&127;First Affiliated Hospital of Fujian Medical University during January 1987 to December 1996. Results Unconditional multiple logistic regression analysis showed that unreasonable use of antibiotics&127;in treatment for acute diarrhea was the major risk factor&127;for chronic diarrhea (OR=5.61, 95％CI of OR=1.15-27.36 with control group I, and OR=16.92, 95％CI of OR=2.67-107.32 with control group II). Chi-square test for trend showed that odds ratio of the use of antibiotics in the cases to the controls increased with the number of antibiotics used in treatment. Conclusion Unreasonable use&127;of antibiotics in treatment for acute diarrhea&127;was an important factor contributing to chronic diarrhea in infants and young children. Early pathogenic diagnosis for diarrh[1] [2] 下一页
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