|
型糖尿病患者TCD及神经心理学研究 |
|
刘国荣 李月春 马丽萍 田丽川
分类号:R395.1 文献标识码:A 文章编号:1005-3611-(2000)01-0034-02
Study on TCD and Neuropsychological Functions in Patients with Type Ⅱ Diabetes
LIU Guorong LI Yuechun et al (Centre Hospital of Bao Tou)
Abstract:Objective:To study the impairment of hemodynamics and neuropsychological functions in patients with type Ⅱ diabetes (NIDDM). Methods:Thirty patients of NIDDM and 50 healthy control subjects were tested with Clinical Memory Scale, WAIS-RC, and measured with TCD of DWL type. Results:Five subtest scores and the MQ of NIDDM group were lower than that of the control group. The VIQ, PIQ and FIQ were significantly lower than that of the controls (P<0.01). TCD shown that 10 arteries of 7 cases were stenosis, the Vm of 7 arteries of other 23 cases were lower than control group. The PI of all were higher than the control group (P<0.01). Peak time of frequency spectrum of 21 cases was prolonged, with S1 peak higher than S2. Conclusion:Patients with NIDDM had poor memory and impairment of intelligence, shown poor ability in learning new materials and impaired hemodynamics. 23.33% of them had artery stenosis, and other patients had arteriosclerosis. Key Words:Type Ⅱ diabetes, TCD, Memory, Intelligence▲
Ⅱ型糖尿病(NIDDM)是合并症最多的一种慢性疾病,但人们常常很少把脑认为是NIDDM合并症的靶器官。最近糖尿病所致中枢神经系统的损害逐渐引起人们的重视[1-3],从脑代谢、神经生化、脑形态学、脑电生理及神经行为学等方面改变的研究进展,提出有糖尿病性脑病的存在[4]。我们对30例NIDDM患者进行了TCD及神经心理功能检查,以期了解其血流动力学及高级神经功能状况。
1 对象与方法
1.1 研究对象 30例NIDDM病人,均符合WHO糖尿病的诊断标准,其中男17例,女13例,年龄31~68岁,平均49.33岁。文盲1例,小学5例,中学15例,中专4例,大学5例。病程1个月~20年,平均7.7年。合并高脂血症者9例,均无神经系统阳性体征,均做了头颅CT检查,8例有轻度脑萎缩,除外脑梗塞及其他脑部病变患者,除外合并高血压、冠心病、心肾功能不全者。 正常对照组50例,男28例,女22例,年龄30~69岁,平均50.56岁。文盲2例,小学8例,中学22例,中专9例,大学9例。 1.2 方法 采用中国科学院心理研究所编制的临床记忆量表进行记忆检查,采用湖南医学院修订韦氏成人智力量表进行智能检查。应用德国产DWL型彩色经颅多普勒诊断仪用2MHZ脉冲多普勒探头经颞窗对病人及正常对照组双侧大脑中动脉(MCA)、大脑前动脉(ACA)、大脑后动脉(PCA)、经枕窗对基底动脉(BA)的平均血流速度(Vm)、脉动指数(PI)、频谱形态进行检测和记录。血管[1] [2] [3] 下一页 上一个医学论文: 一例t 2 14 致自然流产报告 下一个医学论文: 抑郁情绪及负性态度对糖尿病患者血糖控制的影响
|
|
|
|
|
|
|