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胰岛素对糖尿病大鼠内皮素缩血管作用的影响 |
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丁怡 王家富 刘同美 段文卓 宋秀媛 宫建玲
［摘 要］ 目的： 研究高糖血症时胰岛素对内皮素-1（ET-1）缩血管作用的影响。方法： 复制高糖血症大鼠模型；将高糖大鼠和正常大鼠的离体主动脉血管环置于无胰岛素和高于生理浓度（40 mIU/L）胰岛素的KH液中，观察两组大鼠血管对10-9 mol/L ET-1的反应。结果： 高糖大鼠血管对ET-1的反应明显弱于正常大鼠（P＜0.01）；高浓度胰岛素可减弱ET-1对正常大鼠血管的收缩作用（P＜0.01）；胰岛素不能减弱ET-1对高糖大鼠血管的收缩作用。结论： （1）长期高糖血症使血管对ET-1的反应降低；（2）胰岛素可减弱ET-1对正常大鼠血管的收缩作用；（3）长期高糖血症使胰岛素对ET-1缩血管活性的影响减小。
［主题词］ 胰岛素； 内皮缩血管肽类； 主动脉； 高血糖症
［中图分类号］ R587.1；Q578 ［文献标识码］ A
［文章编号］ 1000-4718(2000)10-0894-03
Insulin influences the vasoconstriction caused by
endothelin-1 in the hyperglycemic rat
DING Yi WANG Jia-fu LIU Tong-mei DUAN Wen-zuo SONG Xiu-yuan GONG Jian-ling
（Department of Pathophysiolgy, Weifang Medical College, Weifang 261042, China）
［Abstract］ AIM： To investigate the effects of insulin on aortic constriction caused by endothelin-1(ET-1) in normal and hyperglycemic rats. METHODS： Hyperglycemic rat models were prepared. Two aortic rings were immersed in the Krebs-Hensleit fluid with and without insulin (40 mIU/L) and the responses of rings to 10-9mol/L ET-1 were observed. RESULTS：ET-1 induced more obvious aortic ring constriction in normal rats than those in hyperglycemic rats (P＜0.01). Rings constriction caused by ET-1 were attenuated in normal rats if the rings were immersed in the KH fluid with insulin (P＜0.01), but no obvious changes were found in hyperglycemic rats. CONCLUSION： (1) the vasoconstriction of aortic rings caused by ET-1 can be reduced by hyperglycemia. (2) Insulin can attenuate the aortic response to ET-1. (3) Insulin can not attenuate the vasoconstriction caused by ET-1 in hyperglycemic rats. These results suggest that insulin may affect vasoconstriction caused by ET-1, which may be involved in the pathogenesis of vascular complication in diabetic or insulin resistance condition.
［MeSH］ Insulin; Endothelins; Aorta; Hyperglycemia
内皮素(endothelin, ET)主要由血管内皮细胞产生，血管平滑肌细胞也可产生ET-1，因此血管平滑肌细胞既是ET-[1] [2] 下一页
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