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部队肺结核发病因素的病例对照研究 |
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李升团 张习坦 韩光红 曹务春 范国英 刘元东
【摘要】 目的 研究部队人员肺结核发病的危险因素。方法 采用1∶2配比的病例对照研究对86个病例及153个对照的相关资料进行条件logistic回归分析，计算比值比(OR)。结果 单因素分析中，文化程度、肺结核病例接触史、卡介苗接种史及卡痕等因素的OR值分别为2.19、2.03、0.38和0.54(P＜0.05)。多因素分析中卡痕、肺结核病例接触史和文化程度进入了最终模型，OR值分别为0.36、1.94和2.33。结论 卡介苗接种对预防部队人员结核病有作用，肺结核病例接触史是一个潜在的危险因素。
【关键词】 肺结核病 病例对照研究 卡介苗
Case-control studies on risk factors for pulmonary tuberculosis in servicemen of China
LI Shengtuan,ZHANG Xitan,HAN Guanghong,et al.
Institute for Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071
【Abstract】 Objective To study the risk factors for pulmonary tuberculosis (PTB) in the servicemen of armed forces and lay a basis for its prevention and control. Methods A 1∶2 matched case-control study was carried out in the servicemen, with 86 cases and 153 controls. Data were analyzed with conditional logistic regression with EGRET software. Odds ratios (ORs) were calculated for the relevant factors. Results Single-variable analysis showed that schooling, history of exposure to PTB, history of Bacille Calmette-Guérin (BCG) vaccination and BCG vaccination scar all associated with the incidence of PTB, with ORs of 2.19，2.03，0.38 and 0.54, respectively, and P＜0.05. Multiple logistic regression analysis showed that BCG vaccination scar, history of exposure to PTB and schooling all entered the final regression model, with ORs of 0.36,1.94 and 2.33, respectively. Conclusion It suggested that BCG vaccination could play a role in the prevention of TB in the servicemen, and history of exposure to PTB was a potential risk factor for TB as well.
【Key words】 Pulmonary tuberculosis Case-control study Bacille Calmette-Guérin
影响肺结核发病的因素很多，国内外都进行了大量研究，其中许多研究是用来评价卡介苗的预防效果［1］。由于研究的人群、现场和方法等各不相同，得出的结论也有不少差异。部队是一个特殊的群体，主要以年轻男性为主，具有独特的训练和生活习惯。在1992～1996年部队肺结核报告发病率上升近1.2倍，为了探讨影响部队肺结核发病的因素，为部队肺结核的预防提供参考和依据，我们在1997年进行了部队肺结核发病因素的病例对照研究，结果报告如下。
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