宫颈癌患者血清TNF

李兆艾　严宗哲　赵敏

　　【摘要】　目的：探讨肿瘤坏死因子-α(TNF-α)、可溶性肿瘤坏死因子受体(STNFR)与宫颈癌发生、发展及淋巴转移的关系。方法：用双抗体夹心ELISA法检测宫颈癌42例和宫颈上皮内瘤变(CIN)14例血清TNF-α和STNFRⅠ、STNFRⅡ，并与正常34例对照。结果：宫颈癌患者血清TNF-α、STNFRⅠ、STNFRⅡ以及CIN患者STNFRⅠ、STNFRⅡ水平较正常对照组明显增高(P＜0.01)；Ⅱ期宫颈癌患者血清STNFRⅠ、STNFRⅡ水平与Ⅰ期患者相比，差异无显著性；宫颈癌有淋巴转移组患者血清STNFRⅠ、STNFRⅡ水平明显高于无淋巴转移组(P＜0.0001)；经相关分析STNFRⅠ、STNFRⅡ在宫颈癌、宫颈癌淋巴转移组、宫颈癌无淋巴转移组及正常对照组均呈正相关关系，仅CIN组无明显正相关。结论：TNF-α、STNFR与宫颈癌的发生发展有关，STNFR可能是判断宫颈癌是否发生淋巴转移较好的监测指标，对判断预后有重要价值。
　　【关键词】　宫颈肿瘤；肿瘤坏死因子；受体，可溶性肿瘤坏死因子
　　中图分类号　R737.33

Study of the correlation between clinical feature and serum TNF-α,STNFR level of cervical carcinoma patients

Li Zhaoai,Yan Zongzhe,Zhao Min
（Shanxi Maternal and Child Health Hospital,Taiyuan,030013）

　　Abstract Objective:To explore the correlation among tumor necrosis factor-α(TNF-α),soluble tumor necrosis factor receptor (STNFR) and the occurrence,progress,lymphatic metastasis of cervical carcinoma.Methods:TNF-α,STNFRⅠ,STNFRⅡ were measured by sandwich ELISA in 42 cases of patients with cervical carcinoma,14 cases with cervical intraepithelial neoplasm(CIN) and 34 cases of normal women as the control.Results:The serum TNF-α,STNFRⅠ,STNFRⅡ of cervical carcinoma patients and STNFRⅠ,STNFRⅡ of CIN patients were significantly higher than those in the control group(P＜0.01),STNFRⅠ and STNFRⅡ in cervical carcinoma patients with lymphatic metastasis were significantly higher than those without lymphatic metastasis(P＜0.01).There was a significant positive correlation between STNFRⅠand STNFRⅡin cervical carcinoma group and the control group.Conclusions:TNF-α,STNFR are associated with the oncogenesis and development of cervical carcinoma.There are important practical values to use STNFR as an index of lymphatic metastasis in judging prognosis.
　　Key words　Cervical neoplasms;Tumor necrosis factor;Receptors,Soluble tumor necrosis factor

　　近年研究表明，肿瘤坏死因子-α

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