苯那普利对高血压左室肥厚与QTc离散度的影响

赵晓薇　金智敏

【摘要】目的 探讨苯那普利对高血压左室肥厚(LVH)与QTc离散度(QTcd)的影响。方法 原发性高血压60例用苯那普利治疗6个月,测定治疗前后左室重量指数(LVMI)和QTcd。结果 LVH组患者治疗后LVMI明显减少(P＜0.001),LVH逆转率72%。LVH组QTcd治疗前显著高于无LVH组(69.1±17.3比40.6±11.6mS,P＜0.001),治疗后明显降低(69.1±17.3比43.9±12.6mS,P＜0.001),而无LVH组治疗前后QTcd无明显变化(P＞0.05)。LVH组中LVH逆转者QTcd明显小于未逆转者(38.2±10.4比60.0±16.1ms,P＜0.001)。LVMI与QTcd之间呈正相关(r=0.678,P＜0.001)。结论 高血压LVH时QTcd增大,苯那普利长期治疗使LVMI减少的同时QTcd也明显降低。
【关键词】苯那普利　高血压　左室肥厚　QTc离散度

The effects of benazepril on hypertensive left ventricular hypertrophy and QTc dispersion.

Zhao Xiaowei,Jin Zhimin.
Shanghai Songjiang Central Hospital,Shanghai 201600.

【Abstract】Objective To investigate the effects of benazepril on hypertensive left ventricular hypertrophy(LVH)and QTc dispersion(QTcd).Methods 60 patients with essential hypertension were treated with benazepril for 6 monthes.Their left ventricular mass index(LVMI)and QTcd were measured before and after treatment.Results LVMI was significantly reduced after treatment(P＜0.001)and LVH reversal rate was 72% in LVH group.Before treatment,QTcd of LVH group was obviously higher than that of non- LVH group(69.13±17.3 vs 40.6±11.6ms,P＜0.001).After treatment,QTcd was significantly decreased in LVH group(69.1±17.3 vs 43.9±12.6mS,P＜0.001).In non- LVH group,QTcd showed no obvious change before and after treatment(P＞0.05).QTcd of patients with reversed LVH was less than those with unreversed LVH in LVH group(38.2±10.4 vs 60.0±16.1ms,P＜0.001).There was a positive correlation between LVMI and QTcd(r=0.658,P＜0.001).Conclusion QTcd was increased in hypertensive LVH and long-term treatment of benazepril may significantly reduce LVMI and QTcd.
【Key words】Benazepril　Hypertension　Left ventricular hypertrophy　QTc dispersion

　　高血压左心室肥厚(LVH)是心脏猝死的一个重要危险因素［1］,后者常源于室性心律失常。而体表心电图(ECG)QTc离散度(QTcd)的增高对急性心肌梗死后室速、室颤的发生有很高的预测价值［2］。本文旨在探讨新一代血管紧张素转换酶抑制剂(ACEI)苯那普利(洛汀新)

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