湖北汉族人群对乙肝疫苗免疫应答的水平与HLA

涂正坤　吴雄文　刘　敏　姜晓丹　杨志章　吴　锋　龚非力　赵修竹

　　中国图书分类号　R392.11　R394.5　R311.144　R730.3
　　摘　要　目的：探讨人群对乙肝疫苗免疫应答与HLA遗传多态性的相关性。方法：对52名湖北汉族健康自愿者进行HBV血源疫苗标准全程接种，共3次(第0、1、6月)，末次接种后8 w用酶免疫法(EIA)检测血清抗HBs抗体水平：S/N≥2.1为应答者；S/N＜2.1为无应答者。同时对受试者进行HLA-I类抗原多态性检测。结果：应答者42人(81.0%)，无应答者10人(19.0%)；无应答者与HLA-B39具有显著相关性，RR＝17.5，χ2＝5.22，P＜0.05，而与HLA-B62呈负相关，χ2＝6.41，P＜0.05。结论：在湖北汉族人群中，HLA-B39表型阳性个体对乙肝疫苗免疫应答水平明显低于其他个体，而HLA-B62表型阳性个体明显高于其他个体。
　　关键词　人类白细胞抗原　乙肝疫苗　免疫应答

Association between the feature of the immune response to hepatitis B vaccine and HLA class I polymorphism in a Hubei population of the Han nationality

TU Zheng-Kun ，WU Xiong-Wen， LIU Min et al.
Department of Immunology,Tongji Medical University,Wuhan 430030

　　　Abstract　Objective:To study association between the feature of the immune response to hepatitis B vaccine and HLA genetic polymorphism on human.Methods:52 healthy volunteers of the Han nationality from Hubei province were subjected to a standard course of immunization with HBV plasma vaccine at month 0,1 and 6 successively. 8 weeks after the last immunization,serum level of anti-HBs antibody were assayed with EIA.Individuals with S/N≥2.1 are responders,and S/N＜2.1 are nonresponders. Results:42(81.0%) of the 52 subjects were responders,10(19.0%) individuals were nonresponders.Unresponsiveness of the 10 individuals to hepatitis B vaccine were found to be positively associated with HLA-B39(RR＝17.5,χ2=5.22,P＜0.05) and negatively associated with HLA-B62(χ2=6.41,P＜0.05),as demonstrated by HLA-I antigen polymorphism analysis.Conclusion:The level of immune response to hepatitis B vaccine of individuals bearing HLA-B39 antigen was significantly lower than others,individuals bearing HLA-B62 antigen was significantly higher than others.
　　Key words　HLA　Hepatitis B vaccine　Immune response

　　乙肝疫苗是取自慢性乙型肝炎病毒(HBV)携带者血液、通过灭活并纯化的乙肝表面抗原(HBsAg)，它的问世为乙型肝炎的预防提供了有力的武器，使乙型肝炎及其续发症(慢性肝炎、肝硬化和原发性肝癌等)得到了有效的控制。但并非所

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