复方红景天对大强度训练大鼠免疫功能的调节作用

施建蓉　庄剑青　郭瑞新　李伯勤　曾兆麟　徐伟珍　胡　芳
余上才　王　韧　　胡琪琛　黄瑞馨　

　　中国图书分类号　R392.6
　　摘　要　目的：探讨中医药提高运动成绩、减轻过度训练引致的机体免疫力下降的作用机制。方法：50只大鼠随机分成3组，进行相应的跑台训练和测试。结果：大强度训练大鼠脾细胞抗体形成能力下降、白细胞移动抑制指数升高，且其血浆ACTH和β-EP的含量低于非训练对照组动物。而进行大强度训练的同时服用复方红景天的中药组动物的上述指标均有改善趋势。结论：复方红景天能提高大强度运动大鼠的运动能力及改善其免疫功能的作用可能是通过影响神经内分泌免疫网络实现的。
　　关键词　大强度运动　免疫功能　神经内分泌　复方红景天

The regulation of Rhodiola Crenulata Compound on immune function of rats trained by heavy exercise
SHI Jian-Rong,ZHUANG Jian-Qing,GUO Rui-Xin et al. Shanghai University of Traditional Chinese Medicine,Shanghai 200032

　　Abstract Objective:In order to study the effect of TCM on decreased immune function of the body after heavy exercise(HE) training.Methods:50 rats were divided into three groups in the experiment.Results:A decline in the ability of antibody forming of spleen cells and an increase of the inhibitor moving index of white cells were observed in the rats after heavy exercise training. Meanwhile the contents of ACTH and β-EP in the plasma of the HE rats were lower than that of the normal control.In the group of TCM+HE,the rats were received Rhodiola Crenulata Compound and forced heavy exercise,the above index were improved.This results indicated that this compound was effective in the exercise performance and could enhance immune function of the HE training rats.Conclusion:The effects of the neuroendocrine-immune regulatory circuit were believed to be the possible mechanism for explaining the effect of this compound on promoting the immune function on the rats with heavy exercise training.
　　Key words Heavy exercise training Immune function Neuroendocrine-immune Rhodiola Crenulata Compound

　　　适度的运动可增强机体免疫力，而过度或激烈运动则会降低机体免疫力。对运动员来说，平时大强度的训练和赛期激烈的比赛又是不可避免的，故常发现一些运动员在训练比赛后，机体抵抗力下降，容易感染疾病，以致影响他们的运动能力，甚至停止参加比赛［1］。因此，如何减轻过度训练引致的机体免疫力下降、提高运动成绩成了研究热点。中医药为研究解决上述问题提供了新的途径。本课题观察了大鼠大强度训练模型的免疫功能变化及中药复方红景天对该模型大鼠免疫功能的影响，并探讨其可能的作用机制。

1　材料与方法
1.1　复方红景天煎剂的制备　将红景

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