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骨髓增生异常综合征患者血清可溶性Fas受体水平测定及其意义 |
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体细胞高表达mFas受体有关外，与其血清sFas受体降低，导致过多的FasL与mFas结合，诱导骨髓造血前体细胞过度凋亡有关。相反， MDS-RAEB/RAEB-t患者骨髓原始细胞增多和病态造血，除了与骨髓造血前体细胞mFas受体表达降低有关外，与其血清sFas受体增高，使得FasL被过多的sFas结合，无法与异常的骨髓造血前体细胞的mFas受体结合而诱导其凋亡有关。由此可见，通过调节MDS患者骨髓造血前体细胞mFas受体和血清sFas受体的表达，可能成为治疗MDS的一条新途径。
作者简介：王鲁群，男，34岁，医学硕士，副主任医师，主要从事造血系统疾病的基础和临床研究
作者单位：济南军区总医院血液科，济南250031
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