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血清维生素A SIL |
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王苏芝 王贵吉 袁 琦 裴迎宾
摘 要 目的：探讨血清维生素A、SIL-2R水平与食管癌的关系。方法：以微量荧光法和ELISA法分别对32例术前食管癌病人和32例健康对照者同步进行了血清维生素A和SIL-2R水平的测定。结果：食管癌患者血清中具有抗亚硝胺致癌作用的维生素A水平较对照组低(P＜0.01)的同时，血清SIL-2R水平显著高于对照组(P＜0.01)，IL-2依赖性免疫功能降低。结论：食管癌患者显示的血清维生素A水平降低和SIL-2R水平升高可能与患者的免疫功能异常有关，并提示在食管癌的发生中，血清维生素A的降低和SIL-2R的升高可能存在着某种联系。
关键词 维生素A 可溶性白细胞介素2受体 食管癌
中国图书分类号 R735.1
The study on the relationship between levels of Vitamine A soluble interleukin-2 receptor in serum and esophageal cancer
WANG Su-Zhi,WANG Gui-Ji,YUAN Qi et al.
Department of Biochemistry,Henan Medical College for Workers and Staff Members,Zhenzhou 450003
Abstract Objective：To study the relationship between levels of Vitamine A (Vit A)soluble interleukin-2 receptor in serum and esophageal cancer.Methods：Using methods of microfluorescence and ELISA,the levels of Vit A and SIL-2R in serum were determined for 32 esophageal cancer patients and 32 health controls.Results:The level of Vit A in serum function of the esophageal cancer group was lower than the control group (P＜0.01),which can resist nitrosamine cause cancer,but the level of SIL-2R in serum of the esophageal cancer group was higher than the control group (P＜0.01)at the same time.Conclusion:The immunologic functions depend on IL-2 of the patients might be inhibited.There was probably relationship between the low Vit A level and the high SIL-2R level in serum and the abnormal immunologic functions of the patients with esophageal cancer.The result point out it was possible that there was a relationship between Vit A level and SIL-2R contents.
Key words Vitamine A Soluble interleukin-2 receptor Esophageal cancer
肿瘤患者的免疫功能和肿瘤的发生、发展密切相关。维生素A对于调节细胞的生长、分化与分裂都有密切关系，缺乏维生素A时表皮细胞病变是致癌物入侵的缺口，可见缺乏维生素A的动物抵抗癌变与感染的能力下降。另有证据表明缺乏维生素A时也削弱了整个免疫系统［1］。许多资料表明，体内维生素A缺乏导致许多肿瘤发病率升高。IL-2通过与细胞IL-2受体(IL-2R)结合，调节免疫细胞的增殖功能，发挥抗瘤作用［2］。IL-2R不仅表达于激活的免疫细胞，而且可部分释放于细胞培养上清或血清中，称为可溶性IL-2受体(SIL-2R)。血液病、自身免疫病及实体瘤等患者血清SIL-2R水平显[1] [2] [3] 下一页
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