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脑脊液肿瘤坏死因子测定在中枢神经系统白血病的临床意义 |
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王考庆 吕善根 钟炎皋
摘 要 目的：探讨脑脊液α肿瘤坏死因子(CSF-TNF-α)在中枢神经系统白血病(CNSL)的临床意义。方法：用放射免疫法测定了40例急性白血病患者CSF-TNF-α含量。结果：CNSL患者CSF-TNF-α含量全部升高，与对照组及无CNSL组比较有极显著性差异(P＜0.01)。10例CNSL患者治疗后8例缓解的CSF-TNF-α含量明显下降；1例虽缓解但下降不明显，半月后复发。另1例病情恶化，CSF-TNF-α含量反较治疗前升高。无CNSL组30例患者7例TNF-α增高，随访80 d，有5例确诊为CNSL。结论：CNSL确诊前中枢神经系统(CNS)已受到白血病细胞的浸润；CSF-TNF-α是诊断CNSL的敏感指标，有助于CNSL的早期诊断和疗效监测。
关键词 脑脊液 肿瘤坏死因子α 中枢神经系统白血病
中国图书分类号 R733.7
Clinical significance of cerebrospinal fluid tumor necrosis factor-α in patients with central nervous system leukemia
WANG Kao-Qing， LÜ Shan-Gen，ZHONG Yan-Gao.
Department of Pediatrics，General Hospital of PLA，Beijing 100853
Abstract Objective:To investigate the clinical significance of tumor necrosis factor-α(TNF-α) in cerebrospinal fluid (CSF) in patients with central nervous system leukemia (CNSL). Methods:40 patients with acute leukemia had been involved in this study. TNF-α level in CSF was detected by radioimmunoassay. Results:The cerebrospinal fluid tumor necrosis factor-α (CSF-TNF-α) is significantly elevated in all patients with CNSL compared to those without CNSL and the normal subject (P＜0.01),of the 10 patients with CNSL after treatment,8 of them remitted and the level of CSF-TNF-α decreased remarkable and one remitted but without the level decreasing remarkably ,and it relapsed after 15 days.The condition of the rest one become worse during the treatment,whereas,its indicator increased.TNF-α level elevated in 7 out of 30 acute leukemia patients without CNSL,and 5 patients developed CNSL during the follow up for 80 days.Conclusion:The central nervous system has been invadad by leukemic cells before diagnosis of CNSL;CSF-TNF-α is a sensitive indicator for diagnosis of CNSL,it is of great value for early diagnosis and monitor of treatment.
Key words Cerebrospinal fluid Tumor necros[1] [2] 下一页
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