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增强型体外反搏对冠心病患者血清一氧化氮和丙二醛的影响 |
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钱孝贤 吴伟康 郑振声 詹澄扬 余步云 汤美安 张苗青 赵顺卿 罗汉川 陈国庆
摘 要 目的：探讨增强型体外反搏对冠心病患者血清一氧化氮(NO)和丙二醛(MDA)的影响。方法：采用硝酸盐还原酶法测定69例冠心患者(反搏组31例，药物组38例)和35名正常人血清中NO2-和NO3-的含量，以反映NO的浓度，同时检测血清中MDA的含量，观察冠心病患者增强型体外反搏过程中及反搏后血清NO和MDA的动态变化。结果：治疗前，反搏组和药物组冠心病患者血清NO含量(38.88±17.03) μmol/L，(40.78±7.38) μmol/L明显低于正常人水平(70.86±7.61) μmol/L，P＜0.05。经过3个疗程的增强型体外反搏治疗，患者血中NO含量明显增高(105.47±25.58) μmol/L，P＜0.05，对照组经过6周药物治疗，血中NO也有一定程度的增高(48.52±10.04) μmol/L,但仍低于正常水平。与此相反，治疗前反搏组和药物组冠心病患者血清MDA含量(5.74±0.53) nmol/L,(5.71±0.59) nmol/L明显高于正常人水平(3.87±0.65) nmol/L,P＜0.05。经过3个疗程的增强型体外反搏治疗，患者血中MDA含量明显降低(4.04±0.65) nmol/L，P＜0.05，但药物组经过6周药物治疗，血中MDA无明显变化(5.60±0.55) nmol/L。在增强型体外反搏过程中，随着疗程的增加，冠心病患者血清NO含量逐渐升高，而MDA浓度则逐渐降低。结论：提示增强型体外反搏可促进NO的释放，从而调整内皮功能，并降低MDA的产生，抑制脂质过氧化反应，为增强型体外反搏在临床上的应用提供新的理论依据。
主题词 反搏动术；冠状动脉疾病；一氧化氮；丙二醛
The effect of enhanced external counterpulsation on serum nitric oxide
and malondialdehyde in patients with coronary heart disease
QIAN Xiao-Xian, WU Wei-Kang, ZHENG Zhen-Sheng, ZHAN Cheng-Yang, YU Bu-Yun,
TANG Mei-An, ZHANG Miao-Qing, ZHAO Shun-Qing, LUO Han-Chuan, CHEN Guo-Qing
The Key Laboratory on Assisted Circulation Ministry of Health,
Sun Yat-Sen University of Medical Sciences， Guangzhou (510089)
Abstract AIM:To investigate the effect of enhanced external counterpulsation (EECP) on serum nitric oxide (NO) and malondialdehyde (MDA) in patients with coronary heart disease. METHODS:The serum NO and MDA levels of 69 cases of coronary heart disease and 35 controls were tested. Patients were divided into EECP group (31 cases) and medication group (38 cases). The serum concentrations of NO and MDA were determined before, during and after treatment. RESULTS: The serum NO levels in patients of EECP group and medication group were much lower than that in controls (38.88±17.03) μmol/L and (40.78±7.38) μmol/L vs (70.86&pl[1] [2] [3] 下一页
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