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慢性乙型肝炎患者血清sICAM |
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张绪清 顾长海 张 娟
中国图书分类号 R512.62
摘 要 目的：探讨慢性乙型肝炎(CHB)患者血清可溶性细胞间粘附分子-1(sICAM-1)水平与肝损害的关系。方法：用ELISA检测正常人、慢性无症状HBsAg携带者(AsC)和CHB患者血清sICAM-1。结果：CHB患者血清sICAM-1明显高于正常人和AsC；CHB患者血清sICAM-1水平与其血清门冬氨酸转氨酶(AST)和总胆红素均呈明显正相关，与凝血酶原活动度呈明显负相关；重度CHB患者血清 sICAM-1 明显高于中、轻度CHB。结论：CHB患者血清sICAM-1水平均有不同程度升高，血清sICAM-1水平可作为反映CHB患者肝损害程度的指标之一。
关键词 病毒性肝炎 细胞间粘附分子-1 乙型肝炎病毒
Serum concentration of soluble intercellular adhesion molecule-1(sICAM-1) and its clinical significance in chronic viral hepatitis B
ZHANG Xu-Qing, GU Chang-Hai,ZHANG Juan. Department of Infectious Diseases,Southwest Hospital,the Third Military Medical University, Chongqing 400038
Abstract Objective:To study the relation between serum levels of sICAM-1 and liver damage in patients with chronic viral hepatitis B(CHB). Methods: Serum sICAM-1 of healthy persons,chronic asymtomic HBsAg carriers(AsC) and patients with CHB was measured by ELISA.Results: Serum levels of sICAM-1 in patients with CHB were significantly increased,compared with healthy persons and AsC. There were significantly positive correlation among serum levels of sICAM-1 and serum AST,total bilirubin, and significantly negative correlation between serum levels of sICAM-1 and activity of prothrombin in patients with CHB. Conclusion:Serum levels of sICAM-1 were significantly increased in patients with CHB,and may reflect the damage of liver.
Key words Viral hepatitis ICAM-1 HBV
细胞间粘附分子-1(Intercellular adhesion molecule-1, ICAM-1)属免疫球蛋白超家族成员［1］。与白细胞介素2一样，ICAM-1也存在膜型和可溶性(sICAM-1)两种形式［2］。sICAM-1的总体结构与膜型ICAM-1胞外区结构非常相似［2］。正常人肝细胞缺乏ICAM-1表达，而乙型肝炎患者的肝细胞膜ICAM-1表达明显增强，其表达水平能反映肝组织炎症坏死和肝损害的严重程度，但需作免疫组化分析［3］。许多自身免疫性疾病患者血清sICAM-1水平有明显增高，sICAM-1可以作为许多炎症疾病病情观察的重要免疫学指标［2］。本文拟在探讨慢性乙型肝炎患者血清sICAM-1水平，及其与患者病情、肝功能的关系。
1 材料与方法
1.1 研究对象 正常人7例，男4例，女3例，平均年龄34岁(22～44岁)。慢性HBV感染者38例，男30例，女8例，平均年龄30岁(17～48岁)，其中慢性无症状HBsAg携带者(AsC)6例，轻、中度慢性肝炎各9例，重度慢性肝炎14例，22例经肝活检病理检查证实其诊断。
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