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去甲肾上腺素诱发的家兔肠系膜微血管运动及尼卡地平对其影响 |
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戴 芸 常立功
摘 要 目的：探讨血管运动产生机制及其与电压依赖性钙通道的关系。方法：健康雄性大耳白家兔20只，体重：2.0～2.5kg，以乌拉坦(ip)为基础麻醉，α－氯醛酮(iv)为维持麻醉，应用显微录像静画步进法观察家兔肠系膜局部施加去甲肾上腺素(NA)0.8μg后，诱发出微动脉周期性、节律性的血管运动及静脉注入尼卡地平对其产生的影响。结果：微动脉血管运动频率：(7.08±0.64)counts／min,振幅：(5.51±0.42)μm。血管运动的振幅在同一支微动脉上分布不均，呈节段性。尼卡地平0.25 g·L－1·kg－1和0.5g·L－1·kg－1均扩张微动脉内径、降低血管运动频率及振幅。结论：血管运动的发生与NA及电压依赖性钙通道有一定关系。
主题词 血管舒缩系统；小动脉；尼卡地平；兔
Effects of nicardipine on arteriolar vasomotion in rabbit mesentery
caused by topical application of noradrenaline
DAI Yun，CHANG Li-Gong
Department of Hemorrheology,China-Japan Friendship Institute of Clinical Medical Sciences,Beijing(100029)
Abstract AIM：To further discuss the mechanism of vasomotion and probable relationship between voltage-dependent calcium channel and vasomotion.METHODS:20 male albino rabbits weighting 2.0～2.5kg each were used for the experiment.They were anesthetized with 25% urethan (0.75g/kg) and α－chloralose (30mg/kg).TV Frame-to-Frame analysing method was used to observe the characteristics of arteriolar vasomotion in rabbit mesentery caused by topical application of NA 0.8 μg,as well as the effects of intravenous injection of nicardipine on vasomotion frequency and amplitude.RESULTS：Topical application of NA 0.8μg was conducted to the observation field,vasomotion occured with frequency (7.08±0.54)cpm,amplitude (5.51±0.42)μm；amplitude was not uniform on the same arteriole.Nicardipine at the dosage of 0.25g·L－1·kg－1and 0.50g·L－1·kg－1dilated the diameter and inhibited vasomotion with reduced frequency and amplitude.CONCLUSION:The mechanism underlying vasomotion is related to voltage-dependent calcium channels.
MeSH Vasomotion system;Arterioles;Nicardipine;Rabbits
血管运动(vasomotion)是血管内径周期性、节律性收缩与舒张现象，具有一定的频率与振幅。在许多种属动物的不同血管床上已发现此现象，但血管运动产生及调控的机制尚未完全阐明。目前研究多集中于人工安装观察窗于动物体表，观察生理条件[1] [2] [3] 下一页
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