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消化系统肿瘤患者血浆睾酮 皮质醇含量和T淋巴细胞功能的变化 |
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刘睿智 侯宇川 李 王 路 刘喜春 赵雪俭 孟庆润 张 军 杨 帆
摘 要 目的：探讨癌症患者免疫功能变化与激素含量的关系。方法：用生物测定法检测了肝癌、胃癌、大肠癌患者血浆睾酮、皮质醇的含量及外周血T淋巴细胞丝裂原反应性和IL-2活性。结果：(1)各组肿瘤患者血浆睾酮含量明显低于对照组，而血浆皮质醇含量却显著高于对照组，二者呈显著负相关。外周血T淋巴细胞丝裂原反应性和IL-2活性，均明显低于对照组。不同肿瘤之间上述各项指标比较均无明显差异。(2)血浆皮质醇含量与T淋巴细胞丝裂原反应性及IL-2活性均呈明显的负相关。结论：肿瘤患者T细胞功能被严重抑制，与血浆睾酮和皮质醇含量的变化有关。
主题词 肿瘤；睾酮；皮质醇；白介素-2
Changes of T lymphocytes function and contents of corticosteroids
and testosterone of patients with cancer of digestive system
LIU Rui-Zhi, HOU Yu-Chuan, LI Lu, LIU Xi-Chun, ZHAO Xue-Jian,
MENG Qing-Run， ZHANG Jun, YANG Fan
Lab. of Reproductive Pathophysiology, Norman Bethune University of Medical Science, Changchun (130021)
Abstract AIM and METHODS: To investigate the relationship between immunologic function and hormone level in cancer patient, we studied the plasma testosterone and corticosteroids levels and mitogenesis of T lymphocyte and IL-2 activities of patients with hepatocarcinoma, carcinoma of stomach and intestine as well as controls by using bioassay technique. RESULTS: (1)Compared with the control group, the testosterone level of all cancer groups decreased significantly, and plasma corticosteroids levels were much higher. The two indexes present negative correlation. The mitogenesis of T lymphocytes and IL-2 activity decreased remarkably in comparison with controls. The above indexes had no significant difference among all the cancer groups. (2) The plasma corticosteroids content presented remarkable negative correlation with mitogenesis of T lymphocytes and IL-2 activities. CONCLUSION: T lymphocyte functions of patients were severely depressed, it may be correlated with changes of plasma testosterone and corticosteroids levels.
MeSH Neoplasms; Testosterone; Corticosteroids; Interleukin-2
肿瘤的发生、演变和机体内环境，如机体的免疫状态，神经内分泌调节等密切相关［1，2］。迄今研究表明，恶性肿瘤患者的细胞免疫功能明显低下。并有多方报道，消化系统肿瘤病人常伴有下丘脑-垂体-性腺轴功能紊乱，表现为血浆睾酮水平的下降［1］。但目前有关肿瘤患者细胞免疫功能和神经内分泌状[1] [2] 下一页
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