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拮抗内皮素生物学效应对甘油所致大鼠急性肾功能衰竭的影响 |
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夏晓红 申玉学 石纪才 于占久 何瑞荣
摘 要 目的和方法：在甘油致大鼠急性肾功能衰竭(ARF)模型上，观察外源内皮素(ET)以及心房钠尿肽(ANP)、硝苯吡碇(Nif)和NO前体L-精氨酸(L-Arg)的作用。结果：甘油致大鼠ARF后24 h,肾功能明显受损，血清尿素氮(SUN)，肌酐(Scr)，丙二醛(MDA)，肾皮质钙含量及血浆内皮素(PET)水平均明显高于正常对照组(P＜0.001)。外源性ET可加重ARF大鼠肾损伤，使SUN、Scr、MDA、PET及肾皮质钙含量显著增加，而ANP、Nif和L-Arg则使ARF大鼠SUN、Scr、MDA、PET及肾皮质钙含量明显降低，肾组织cGMP含量增加，减轻肾小管损伤。结论：ET对ARF的发生发展具有重要意义，ANP、Nif和L-Arg可通过不同途径拮抗ET的生物学效应，从而对ARF的防治起到积极的作用。
主题词 内皮缩血管肽；心钠素；硝苯地平；精氨酸；肾功能衰竭，急性
Effects of antagonizing the biological actions of endothelin on glycerol-induced acute renal failure
XIA Xiao-Hong, HE Rui-Rong1，SHEN Yu-Xue, SHI Ji-Cai, YU Zhan-Jiu
Hebei Academy of Medical Sciences, Shijiazhuang(050021) 1Hebei Medical University, Shijiazhuang
Abstract AIM and METHODS：The effects of atrial natriuretic peptide (ANP), nifidepine (Nif) and L-arginine (L-Arg), the physiological NO precursor were observed on a model of glycerol-induced acute renal failure (ARF) of rat, respectively. RESULTS：The impairment of renal function was exaggerated, as manifested by significant increases in serum urea nitrogen(SUN),serum creatinine (Scr), MDA, PET and the contents of calcium of renal cortex. Exogenous endothelin (ET) might exaggerate the renal injury of ARF rats, and significantly increase the levels of SUN, Scr, MDA, PET and calcium contents of renal cortex, while ANP, Nif and L-Arg could decrease the level of SUN, Scr, MDA, PET and calcium contents of renal cortex, and increase contents of cGMP of renal tissue, and attenuate the renal tubular injury.CONCLUSION：ET have the potential pathogenetic role in the glycerol induced ARF. ANP, Nif and L-Arg could block the biological actions of ET via different ways, thereby affording the protective action against ARF.
MeSH Endothelins; Atrial natriuretic factor; Nifedipine; Arginine; Kidney failure, acute
内皮素(endothelin, ET)是血管内皮细胞分泌的，迄今所知体内最强的缩血管活性多肽［1］。最近研究发现，ET对肾脏功能的调控及肾脏疾病的发生发展起着十分重要的作用［2］。因此，如能减少ET的合成和释放，抑[1] [2] 下一页
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