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福州市妇女乳腺癌危险因素的病例对照研究 |
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史习舜 吴彬 胡志坚 蔡婉津 郑建莉
摘要:[目的] 探讨福州市女性乳腺癌的危险因素。 [方法] 对近2年在福州市各大医院进行手术并经病理确诊为乳腺癌的145名患者开展1∶1配对的病例对照研究。资料使用Epi-Info软件和SAS 6.04版软件进行统计分析。[结果] 单因素分析,达到统计学显著性水平的危险因素有乳腺良性疾病史、BMI指数高、初潮年龄早、肿瘤家族史、初产年龄大、流产次数多、未产年龄大和行经时乳房涨痛。哺乳和饮用井水是保护因素。条件Logistic回归分析显示初潮年龄早、乳腺良性疾病史、肿瘤家族史及流产次数多是乳腺癌的危险因素,而哺乳和饮用井水是保护因素。[结论] 福州市女性乳腺癌的危险因素是:乳腺良性疾病史、初潮年龄早、肿瘤家族史及流产次数多。 关键词: 乳腺癌; 危险因素; 病例对照研究; 条件Logistic; 1∶1配对 中图分类号:R 737.9 文献标识码: A 文章编号:1007-2705(2000)05-0012-03
A Case-control Study on Risk Factors of Breast Cancer for Women in Fuzhou
SHI Xi-shun, WU Bin, HU Zhi-jian, et al. (Fujian Medical University, Fuzhou,350004 China)
Abstract:[Objective] To detect the risk factors of breast cancer for women in Fuzhou. [Methods] To study 145 cases with breast cancer by 1:1 match case-control study. To analyze the data with the Epi-Info and SAS 6.04 packages. [Results] In the one-way analysis, the risk factors of breast cancer are history of benign breast diseases, high body mass index, early age at menarche, family history of carcinoma, late age at primiparity, high frequency of abortion, a large age at last parturition, and swell or pain in breast during menstruating. In conditional logistic regression model, early age at menarche, history of benign breast diseases, family history of carcinoma, high frequency of abortion are risk factors, while breast feeding and drinking well water are protective factors. [Conclusion] The risk factors of breast cancer for women in Fuzhou are history of benign breast diseases, early age at menarche, family history of carcinoma and high frequency of abortion. Key words: breast cancer; risk factor; case-control study; 1:1 match; conditional logistic regression
乳腺癌在西欧和北美高发区是严重威胁妇女健康的常见恶性肿瘤。近10来年我国的发病率呈上升趋势,据预测到2000年,我国女性恶性肿瘤标化发病率乳腺癌将居首位[1]。因此,研究乳腺癌的危险因素,提出合理的预防措施,仍有其现实意义。
1 材料和方法
1.1 研究对象 采用1∶1配对的病例对照研究。病例选择1998年6月~2000年5月在福州市各大医院手术经病理确诊[1] [2] 下一页 上一个医学论文: 三明市实施计划免疫20年成本 下一个医学论文: 污水等环境中O157大肠杆菌的研究
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