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早产合并临床绒毛膜羊膜炎时母血和脐血中细胞因子的检测 |
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刘素英 夏振开 高美华 王海燕 胡 涛
中国图书分类号 R392
摘 要 目的：探讨早产合并临床绒毛膜羊膜炎时母血和脐血中细胞因子的变化。方法：应用ELISA法测定31例早产合并临床绒毛膜羊膜炎孕妇(A组)外周血和脐血中肿瘤坏死因子(TNFα)、白细胞介素6(IL-6)和白细胞介素8(IL-8)含量，并以35例早产孕妇作对照(B组)。结果：A组母血中TNFα、IL-8均显著高于B组(P＜0.05)，脐血中IL-6显著高于B组(P＜0.02)，母血中IL-6，脐血中TNFα和IL-8在A、B两组中无显著性差异。结论：早产合并临床绒毛膜羊膜炎时细胞免疫功能增强。
关键词 早产 绒毛膜羊膜炎 细胞因子
Maternal and umbilcal cord serum cytokines level in preterm labor with clinical chorioamnitis
LIU Su-Ying, XIA Zhen-Kai, Gao Mei-Hua et al.
Department of Obstetrics and Gynecology, Affiliated Hospital of Binzhou Medical College, Binzhou 256603
Abstract Objective：To investigate the change of cytokines of maternal and umbilical cord serum in preterm labor with clinical chorioamnitis. Methods：31 women with chorioamnitis between 29 and 36 weeks gestation( group A) were studied and 35 women without chorioamnitis were delivered between 28 and 36 weeks gestation (group B) as control, TNFα、IL-6 and IL-8 were measured by Enzyme-linked immunosorbent assay. Results: TNFα and IL-8 concentrations in maternal sera in group A were significantly higher than those in group B(P＜0.05) and IL-6 concentrations in umbililcal cord sera in group A were significantly higher than that in group B(P＜0.02), no significant difference in maternal IL-6, umbilical cord TNFα and IL-8 concentrations were noted in both groups. Conclusion: For patients with preterm labor and clinical chorioamnitis the cell-mediated immunity is activated.
Key words Preterm labor Chorioamnitis Cytokines
早产的病因至今不清楚，宫内感染与早产有一定的关系。国外资料报道早产和宫内感染时羊水中某些细胞因子含量显著升高。本文旨在探讨早产合并临床绒毛膜羊膜炎时母血和脐血中TNFα、IL-6、IL-8的变化及临床意义。
1 材料与方法
1.1 病例选择 早产孕妇66例，其中合并临床绒毛膜羊膜炎31例(A组)，平均年龄26.5岁(25～28岁)，平均孕周为32.5 w(29～36 w)，B组平均孕周32 w(28～36 w)，两组均为初产妇，两组孕周、年龄均无显著性差异，所有孕妇均无其它系统的感染，也无其他妊娠合并症或妊娠并发症。
1.2 临床绒毛膜羊膜炎的诊断标准 孕妇体温≥38℃及至少有下列四项中的一项：①孕妇心率≥100次／min；②子宫触痛；③白细胞≥1.5×109 [1] [2] [3] 下一页
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