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一氧化氮 内皮素和循环内皮细胞在支气管哮喘中的作用研究 |
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蒋东波 李华强 史源 潘捷 沈际皋 杨映波 冯素珍 李天星 徐有奇
摘 要 目的：探讨一氧化氮、内皮素和循环内皮细胞在支气管哮喘中的作用。方法：哮喘患儿61例，40名健康儿童为对照，测定其血浆NO-2/NO-3、ET、cGMP和循环内皮细胞(CEC)水平，用过敏性哮喘豚鼠进行验证。结果：哮喘患儿血浆NO-2/NO-3、cGMP和CEC水平均明显升高(P＜0.05～0.01)，其中重度哮喘患儿血浆NO-2/NO-3和CEC水平较轻中度哮喘患儿更高(P均＜0.01)；重度哮喘患儿血浆ET水平明显升高(P＜0.01)；哮喘患儿血浆NO-2/NO-3与cGMP和CEC水平呈显著正相关(P＜0.05～0.01)。过敏性哮喘豚鼠BALF中NO-2/NO-3、ET及cGMP水平均明显升高(P均＜0.01)；血浆中cGMP和CEC水平亦升高(P均＜0.05)；糖皮质激素可降低NO-2/NO-3、ET、cGMP和CEC水平。结论：哮喘时NO-2/NO-3、ET和CEC产生过多，它们在哮喘发病机制中占有重要地位，而且血浆ET和CEC水平可能与哮喘病情相关。
主题词 哮喘；一氧化氮；内皮缩血管肽类；内皮；细胞；儿童；豚鼠
Roles of NO, ET and CEC in the pathogenesis of asthma
JIANG Dong-Bo, LI Hua-Qiang, SHI Yuan, PAN Jie, SHEN Ji-Gao,
YANG Ying-Bo, FENG Su-Zhen, LI Tian-Xing, XU You-Qi
Daping Hospital, and the Institute of Surgery. Third Military Medical College, Chongqing(400042)
Abstract AIM:To investigate the roles of NO,endothelin(ET) and circulating endothelial cells (CEC) in the pathogenesis of asthma. METHODS：Plasma nitrite and nitrate (NO-2/NO-3), ET, cGMP and CEC levels in 61 asthmatic children and 40 matched normal children were examined. In addition, the plasma and bronchoalveolar lavege fluid (BALF) NO-2/NO-3, ET, cGMP and CEC levels in guinea-pigs with allergic asthma were determined.RESULTS：Asthmatic children had increased amounts of NO-2/NO-3, cGMP and CEC compared with normal control subjects (P＜0.05, P＜0.01).Among them, 15 severe asthmatic children had significantly higher levels of ET than normal subjects (P＜0.01). Elevations of NO-2/NO-3 were correlated with cGMP and CEC(P＜0.05,P＜0.01). Guinea-pigs with allergic asthma had increased amounts of NO-2/NO-3,ET and cGMP in BALF than normal control subjects (P＜0.01),so did cGMP and CEC in plasms(P＜0.05). Glucocorticoid may have reduced NO-2/NO-3, ET, cGMP and CEC contents and even have therapeutic effects.CONCLUSIONS：There were increased production of NO-2/NO-3, ET, and CEC in asthma, they may play an important roles in the pathogenes[1] [2] 下一页
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