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自发性高血压大鼠高胰岛素血症对血管反应性的影响及药物干预的实验研究 |
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朱吉垒 万军 杨顺裕 康巧珍 毛方方 张心怡 代政德
摘 要 目的和方法：研究自发性高血压大鼠(SHR)及合并高胰岛素血症时血管反应性的差异及血管紧张素转化酶抑制剂(苯那普利，benazerpril)、“九七黄”(复合制剂，Jiu qi huang)对其影响。SHR喂养高糖饲料形成高胰岛素血症观察SHR及SHR合并高胰岛素血症时血管对缩血管物质及舒血管物质的反应性改变，及用苯那普利，苯那普利与“九七黄”合用时血管反应性的改变；及各组血液亚硝酸盐(NO2)、内皮素(ET)、血栓素(TXA2)、前列腺环素(PGI2)的变化。结果：高胰岛素血症可使血管对缩血管物质反应性增强，对舒血管物质反应性减弱。苯那普利在降低高胰岛素血症的同时使血管对缩血管物质及舒血管物质的反应性有所改善；但加用“九七黄”后，这种改善作用更显著。结论：高胰岛素血症可使SHR血管对缩血管物质反应性增强，对舒血管物质反应减弱。苯那普利、“九七黄”可改善这种异常作用，这些均与体内血管活性物质一氧化氮(NO)、PGI2降低，ET、TXA2升高有关。苯那普利、“九七黄”的改善作用也与NO、PGI2升高，ET、TAX2降低有关。
主题词 高血压；高胰岛素血症；血管反应性
The effect of hyperinsulinemia in spontaneously hypertensive rats on vascular responsiveness
and the effects of drugs
ZHU Ji-Lei,WAN Jun,YANG Shun-Yu,KANG Qiao-Zhen,MAO Fang-Fang,ZHANG Xin-Yi,DAI Zheng-De
Department of Internal Medicine of Wuhan 5th Municipal Hospital (Wuhan,430050)
Abstract AIM:To investigate variations of vascular responsiveness in spontaneously hypertensive rats(SHR) with or without hyperinsulinemia and the effect of benazerpril and Jiu Qi Huang on it. METHODS：Spontaneously hypertensive rats were fed a diet containing high glucose for 4 weeks to result in hyperinsulinemia. The difference of vascular reactivity of SHR and SHR with hyperinsulinemia were studied.The effect of benazerpril and benazerpril with Jiu Qi Huang on vascular reactivity of SHR with hyperinsulinemia and blood NO,ET TXA2，PGI2 were also observed.RESULTS：Hyperinsulinemia resulted in higher vascular reactivity than adrenaline and lower than isoprenaline. Benazerpril decreased hyperinsulinemia and improved vascular responsiveness, but benazerpril with Jiu Qi Huang had even more significant results than those of benazerpril alone.CONCLUSION：Hyperinsulinemia resulted in higher vascular responsiveness of SHR than adrenaline and lower than isoprenaline. Benazerpril,Jiu Qi Huang improved these effects.These effects may be relate[1] [2] 下一页
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