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神经激肽B受体在猫三叉神经脊束核尾侧亚核和脊髓内的分布 |
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吕葆真 丁玉强 王丹 张淼丽
【摘要】 目的 了解神经激肽B受体(NK3受体)与伤害性信息的传递和调制的可能关系，调查NK3受体在三叉神经尾侧亚核和脊髓内的分布状况。 方法 免疫组织化学技术。 结果 NK3受体样免疫反应产物在三叉神经尾侧亚核和脊髓内的分布基本一致。致密的免疫反应产物分布于Ⅱ内层(inner part)，而Ⅰ层和Ⅱ外层(outer part)染色浅淡。NK3受体阳性神经元胞体主要见于三叉神经尾侧亚核和脊髓的Ⅰ层和Ⅱ层，少量分布于脊髓后角深层。 结论 提示三叉神经尾侧亚核和脊髓内的NK3受体可能与初级伤害性信息的传递和调控有密切关系。
【关键词】 神经激肽B受体 三叉神经尾侧亚核 脊髓 免疫组织化学 猫
DISTRIBUTION OF NEUROKININ B RECEPTOR (NK3) IN THE CAUDAL
SPINAL TRIGEMINAL NUCLEUS AND SPINAL CORD OF THE CAT
Baozhen, Ding Yuqiang△, Wang Dan, Zhang Miaoli
(Department of Anatomy and K.K.Leung Brain Research Center,
The Fourth Military Medical University, Xi an)
【Abstract】 Objectives In order to study possible relationship between neurokinin B receptor(NK3) and transmission and modulation of noxious sensory information, we investigated the distribution of NK3 receptor in the caudal spinal trigeminal nucleus and spinal cord of the cat. Method Immunohistochemical staining was used. Results The distribution pattern of NK3 receptor-like immunoreactivity (-LI) in the spinal cord was similar to that of the caudal spinal trigeminal nucleus. Intense NK3 receptor-LI was observed in the inner part of lamina Ⅱ of the caudal spinal trigeminal nucleus and spinal cord; Weak NK3 receptor-LI was seen in lamina Ⅰ and outer part of lamina Ⅱ. Neuronal cell bodies with NK3 receptor-LI were mainly found in laminae Ⅰ and Ⅱ of the caudal spinal trigeminal nucleus and spinal dorsal horn, and a few were distributed in the deeper layers of the spinal dorsal horn. Conclusion The results suggest that NK3 receptor might be involved in the transmission and modulation of primary noxious information in the caudal spinal trigeminal nucleus and spinal cord of the cat.
【Key words】 Neurokinin B receptor; Caudal spinal trigeminal nucleus; Spinal cord; Immunohistochemistry; Cat
速激肽家族主要由P物质、K物质和神经激肽B(NKB，亦称nenromedin K)组成，它们广泛分布于神经系统内，并具有多种重要的生理功能［1］。3种速激肽的生理作用是通过各自的受体介导实[1] [2] 下一页
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