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福建省五型病毒性肝炎流行特征 |
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李凌奋1 何家鑫1 赵莉莱1 周 勇1 夏 胜1 王枝新1 原寿基2 王成钦1
摘要 为了解福建省人群病毒性肝炎流行特征，福建省于1992年进行五型病毒性肝炎感染的血清流行病学调查。采用多阶段分层整群随机抽样法，采集福建省疾病监测点自然人群的1 237户家庭中1～59岁居民血样本3 809份。采用RIA法检测HBsAg、抗-HBs、抗-HBc，采用EIA法检测抗-HAV、抗-HCV、抗-HDV、抗-HEV和HBeAg。结果显示各标化流行率为HAV 76.60%、HBV 77.26%、HCV 3.99%、HDV 2.10%、HEV 18.80%、HBsAg 17.25%、抗-HBs 34.33%、抗-HBc 68.58%、HBeAg 8.42%。农村HAV、HBV、HEV流行率均高于城市。HBsAg流行率出现儿童峰和成人峰而且男性高于女性。HBV和HEV感染有明显的家庭聚集性。青壮年HEV流行率高，城市儿童HAV流行率低。提示福建省是HAV、HBV、HCV、HEV的高流行区。预防甲、乙型肝炎病毒感染最有效策略是免疫接种甲、乙型肝炎疫苗。
关键词 病毒性肝炎 流行病学
Epidemiologic Features of Viral Hepatitis in Fujian Li Lingfen*, He Jiaxin,Zhao Lilai, et al.* Fujian Provincial Anti-Epidemic Station,Fuzhou 350001
Abstract To study the prevalence and the epidemiologic features of viral hepatitis in Fujian,a seroepidemiological survey on five kinds of viral hepatitis infection has been carried out in Fujian province since 1992.Using stratified mulitistage random cluster sampling,3 809 serum samples were collected from 1 237 families in general population in the disease surveillance points in Fujian province.HBsAg,anti-HBs and anti-HBc were screened by RIA and HBeAg,anti-HAV,anti-HCV anti-HDV anti-HEV were by EIA.The results showed that the standardized prevalence rates of HAV,HBV,HCV,HDV,HEV,HBsAg,anti-HBs,anti-HBc and HBeAg were 76.60%,77.26%,3.99%,2.10%,18.80%,17.25%,34.33%,68.58% and 8.42% respectively.The HAV,HBV,HEV prevalence rates in rural were higher than in urban areas.The HBsAg prevalence rate among males was higher than females,with peaks evidenced in 5-9 years old and 20-29 years old.There seemed to be significant family clusterings of HBV and HEV infection.There was higher HEV prevalence rate among the young-robusts but lower HAV prevalence rate among children in urban areas.These results suggested that Fujian is a highly prevalent area for HAV,HBV,HCV and HEV infections.Thus HA and HB vaccination should play as the most effective strategy in the prevention of HAV and HBV infect[1] [2] 下一页
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