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肾缺血预处理增强心脏的电稳定性 |
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冯志强 冉 兵 张春来 盘强文 李莉华 林海英 李先华
摘 要 目的：研究肾缺血预处理(IPC)对心脏电稳定性的影响和机理。方法：24只大耳白兔随机分为对照组、肾缺血再灌流(I/R)组和肾IPC+I/R组。观察肾再灌流24 h时及用垂体后叶素(Pt)和肾上腺素(Adr)后的心电图动态变化以及血中一氧化氮(NO)和心肌中丙二醛(MDA)的浓度改变。结果：用Pt和Adr后，肾I/R组缺血性ST段抬高和心律失常发生率同肾IPC+I/R组差异显著；肾IPC+I/R组NO代谢物升高和MDA降低同I/R组差异显著(P＜0.05)；除MDA外，上述指标在肾IPC+I/R组 与对照组间差异无显著。结论：肾IPC通过减轻心肌缺血性改变使心脏电稳定性增强；NO可能通过增加氧自由基的清除和扩血管效应而参与此作用。
主题词 局部缺血；肾；心脏；再灌注
The increase in electrocardiac stability by kidney ischemic preconditioning
FENG Zhi-Chiang, RAN Bin, ZHANG Chun-Lai, PAN Chiang-Wen,
LI Li-Hua, LIn Hai-Ying, LI Xian-Hua
Department of Physiology, Luzhou Medical College, Luzhou(646000)
Abstract AIM: The effect of kidney ischemic preconditioning on electrocardiac stability and it s mechanism were studied in the article. METHODS：24 adult Japanese white rabbits were randomly divided into three groups: control group (n=6), left renal artery (LRA) received no clamping; ischemic reperfusion (I/R) group (n=9),LRA received clamping for 1 hour followed by 24 hours of reperfusion; ischemic preconditioning (IPC) and I/R group (n=9), LRA received clamping for 5 minutes followed by 10 minutes of reperfusion, which was done repeatedly 3 times, then, do the same process again as in I/R group. The dynamic changes of electrocardiogram were observed at 24th hour of reperfusion and after intravenous pituitrin (Pt) 2U．kg-1 for 10 minutes and adrenalin (Adr) 0.03 mg．kg-1 for 15 minutes. Concentration of nitric oxide (NO) in blood and molonyldehyde (MDA) content in cardiac tissue were chected in three groups. RESULTS：There was a considerable difference in the ischemic ST segment elevation and also in arrhythmogenic rate between I/R group (0.270±0.160 mV, 88.89%) and IPC+I/R group (0.090±0.300 mV, 22.22%) after Pt and Adr administration. In addition, there was a significant difference (P＜0.05) increase in NO and decline in MDA in IPC+I/R group (176.750±69.057, 12.540[1] [2] [3] 下一页
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