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山东省丁型肝炎病毒感染调查研究 |
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陈宪锐1 玄梅香2 尹燕明1 周玉霞1 魏佑农3 赵新平4 付春生5
摘要 为了解山东省丁型肝炎病毒感染状况，并探讨丁型肝炎病毒(HDV)感染与乙型肝炎病毒(HBV)感染的关系，应用酶联免疫吸附试验(ELISA)对山东省2 681例乙型肝炎病毒感染者进行了血清丁型肝炎病毒抗体(抗-HDV)检测，共检出抗-HDV阳性者207例，阳性率7.72%。HBsAg携带者组抗-HDV阳性率3.16%，乙肝患者组抗-HDV阳性率13.15%，两组之间的差异有非常显著性(P<0.001)。在乙肝患者组中，慢性活动性肝炎患者和重症肝炎患者抗-HDV阳性率高于急性肝炎患者和慢性迁延性肝炎患者，差异有非常显著性(P<0.001)，表明乙肝病史越长、病情越重，其抗-HDV阳性率越高。提示乙肝患者联合或重叠感染HDV与乙肝慢性化和病情加重的形成有关。
关键词 丁型肝炎病毒 丁型肝炎病毒抗体 乙型肝炎病毒 乙型肝炎表面抗原
Study of HDV Infection in Shandong Province (1994-1997) Chen Xianrui*,Xuan Meixiang,Yin Yanming,et al. * Taishan Medical College,Taian 271000
Abstract To understand the situation of HDV infection in Shandong province and to explore the relationship between HDV and HBV infections,2681 samples infected with HBV were tested for serum anti-HDV with enzyme linked immunosorbent assay,in Shandong.Among them,207(7.72%) were found to be anti-HDV positive.Anti-HDV positive rates in HBsAg carriers and in hepatitis B patients were 3.16% and 13.15%,respectively.A significant difference (P<0.001) was noticed between the two groups.In the second group,anti-HDV positive rates in patients with chronic active hepatitis and severe hepatitis were both higher than those in patients with acute hepatitis and chronic persistent hepatitis and the difference was significant (P<0.001).The longer the history and the more severe the condition the higher of the anti-HDV positive rate was seen.The results indicated that the combined and over-lapping HDV infections were both responsible for the chronic status of hepatitis B and its deterioration.
Key words HDV Anti-HDV HBV Hepatitis B surface antigen
丁型肝炎是由丁型肝炎病毒(HDV)引起的，HDV是1977年意大利学者Rizzetto发现的，当时称之为δ抗原(δ-Ag)，它是一种分子量很小的缺陷性嗜肝RNA病毒，HDV内部系由HDV基因组和HDAg组成，包绕有乙型肝炎表面抗原(HBsAg)的外膜，乙型肝炎病毒(HBV)感染为HDV提供HBsAg的包膜，所以，HDV需有HBV辅助才能复制，故临床上表现为与HBV联合或重叠感染。由于我国人群HBV感染率较高，故了解HDV感染状况及其与乙肝的关系，对于防治HDV感染是十分重要的。1994年10月至1997年1月，在山东省的10个地市随机对2 681例HBV感染者进行了血清抗-HDV检测研究。现报告如下。
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