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HIV AIDS与肝炎病毒感染者CD4 CD8 淋巴细胞数的比较 |
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刘顺爱 秦靖 张卫华 张启云 徐克沂
摘 要 目的：探讨HIV携带者或AIDS病人(简称HIV/AIDS)与肝炎病毒感染者的CD4+、CD8+淋巴细胞变化，并进行比较。方法：用免疫磁珠法(DYNA beads)检测CD4+、CD8+T淋巴细胞数，用双侧t检验进行统计学处理。结果：全部HIV/AIDS的CD4+T淋巴细胞降低，且幅度大，83.4%低于500细胞/μl。在病毒性肝炎中降低的百分比和幅度均明显低于前者，只有28.8%低于500细胞/μl,且24.2%大于800细胞/μl。与同一水平CD4+细胞相对应的HIV/AIDS CD8+T淋巴细胞水平显著高于病毒性肝炎，CD8+细胞水平随CD4+T细胞增加而升高。CD4+细胞平均水平较高的HIV感染者自觉症状与CD4+T细胞数之间无直接相关关系，说明只用CD4+T细胞数来估计病人机体状态或只根据病人症状估计机体免疫状态是不太准确的。结论：HIV/AIDS与病毒性肝炎存在不同程度的CD4+、CD8+T淋巴细胞异常；CD4+T细胞是HIV/AIDS的重要指标，但不是绝对指标；CD8+T细胞与病人病情的变化及预后之间可能存在着很重要的关系，需进一步研究。
关键词 HIV/AIDS 病毒性肝炎 CD4+T细胞 CD8+T细胞
中国图书分类号 R446.63
Compare the counts of CD4+、CD8+T lymphocyte in HIV/AIDS and hepatitis patients
LIU Shun-Ai, QIN Jing,ZHANG Wei-Hua et al.
Virus Study Laboratory of Beijing Ditan Hospital,Beijing 100011
Abstract Objective:To study and discuss the change of CD4+、CD8+T lymphocyte in HIV/AIDS and viral hepatitis patients.Methods：DYNA beads method was performed to count the CD4+，CD8+T lymphocyte.Statistical analysis was done using bio-t test.Results: CD4+T lymphocyte counts in all of the HIV/AIDS patients were much lower than healthy people,83.4% of them were lower than 500 cell/μl.CD4+ T lymphocyte counts decreased in hepatitis too, but only 28.8% were lower than 500 cell/μl,24.2% were higher than 800 cell/μl. CD8+T lymphocyte counts were much higher in HIV/AIDS patients than in hepatitis patients with same CD4+T lymphocyte level. There was not direct correlation between sympton and CD4+ T lymphocyte level in HIV infected person,so can neither estimate the condition of patients only use CD4+ T lymphocyte counts nor estimate the immune status only with the patients condition.Conclusion:Both HIV/AIDS and viral hepatitis have abnormal CD4+,CD8+T lymphocyte counts at different level.CD4+T lymphocyte counts is an important parameter in HIV/AIDS,but it is not an absolute parameter.There might be a very important relationship exist between CD8+T[1] [2] [3] 下一页
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