|
肺癌患者红细胞CR1基因密度型分布与红细胞免疫变化的研究 |
| |
王若霞 郭峰 张俊洁 赵书平
【摘要】 目的 检测32例肺癌患者红细胞CR1基因密度型分布、红细胞免疫粘附肿瘤细胞功能及SOD酶活性、β-内啡肽含量。方法 PCR法检测红细胞CR1基因密度多态性；红细胞花环法检测红细胞免疫粘附肿瘤细胞能力；放免法测定SOD酶活性；RIA法测定β-内啡肽含量。结果 经与31例正常人比较显示：肺癌患者CR1基因密度多态性分布与正常人不一致(χ2=3.19,P＜0.05)；红细胞免疫功能及SOD酶活性较正常人明显降低(P＜0.01)；β-内啡肽较正常人明显升高(P＜0.01)。同时还发现肺癌患者的红细胞粘附肿瘤细胞功能与SOD酶活性呈正相关(r=0.39.P＜0.05)。结论 肺癌患者红细胞免疫功能低下；SOD酶活性降低；β-内啡肽含量升高有部分与红细胞CR1基因密度型改变有关。
【主题词】 肺肿瘤 红细胞免疫 CR1基因密度 超氧化物歧化酶 β-内啡肽
Distribution of erythrocyte CR1 genomic density polymorphism and changes of erythrocyte immunity in pulmonary cancer patients Wang Ruoxia*,Guo Feng,Zhang Junjie, et al.*Department of Respira- tory,Chinese PLA No 476 Hospital,Fuzhou 350002
【Abstract】 The distribution of erythrocyte CR1 density gene types,erythrocyte immune adhesion tumour cell function,SOD activity, concentration of β-endorphin in 32 cases with pulmonary cancer were measured and compared with 31 cases of normal control group.The results showed the multiple distribution of erythrocyte CR1 density gene types in pulmonary cancer patients were different from normal control group(χ2=3.91,P＜0.05).The erythrocyte immune function and SOD activity were significantly decreased,but the concentration of β-endorphin were significantly elevated (P＜0.01),as well as there was a positive correlation between erythrocyte immune adhesion tumour cell function and SOD activity in pulmonary cancer patients(r=0.39,P＜0.05).These results suggested that all erythrocyte immune function decreased,SOD activity decreased and elevation of β-endorphin had partial relationship to the changes of erythrocyte CR1 density gene types.
【Subject words】 Lung neoplasms Erythrocyte immunity CR1 density polymorphism Superoxide dismutase β-Endorphin
自1981年Siegel等提出“红细胞免疫系统”新概念以来，国内外学者在红细胞免疫领域进行了广泛深入的研究。认为红细胞参与抗肿瘤免疫反应释放NK细胞激活因子及CR1(补体C3b受体，CD35)与红细胞免疫粘附功能关系最密切。Currie等采用抗CR1的单克隆抗体检测Hodgkis病、肺癌等病人的CR1密度，发现其较正常人减少近一[1] [2] [3] 下一页
上一个医学论文： 皮质醇导致脓毒症大鼠TNF
下一个医学论文： 白细胞移动抑制因子 LMIF 释放的测定及条件性抑制LMIF的作用
|
|
|
|
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 基础医学论文 >> 正文