|
慢性支气管炎患者HLA |
| |
彭则 李建强 王崇刚 刘卓拉 宋满景
【摘要】 目的 研究单纯的慢性支气管炎和煤工尘肺合并慢性支气管炎患者的HLA-DRB1等位基因的异同。方法 采用顺序特异性引物聚合酶链反应技术，检测了山西省汉族的37例单纯慢性支气管炎和33例煤工尘肺合并慢性支气管炎患者的HLA-DRB1等位基因频率，并与山西省正常人群进行比较分析。结果 单纯慢性支气管炎组的HLA-DRB1*120X基因频率明显增高（24.3%），而煤工尘肺合并慢性支气管炎组的HLA-DRB1*040X基因频率明显增高（22.7%），其他等位基因频率在3组之间差异无显著性。结论 在山西省汉族人群中，HLA-DRB1*120X与单纯慢性支气管炎有关联，而HLA-DRB1*040X与煤工尘肺合并慢性支气管炎有关联。
【关键词】 基因 支气管炎 尘肺 聚合酶链反应
Analysis of HLA-DRB1 Allele in Patients with Chronic Bronchitis Peng Ze, Li Jianqiang, Wang Chonggang, et al. Department of Respiratory Diseases, The Second Hospital of Shanxi Medical University, Taiyuan 030001
【Abstract】 Objective To study the difference in HLA-DRB1 allele frequencies between patients with simple chronic bronchitis and with coal worker s pneumoconiosis (CWP) complicated with chronic bronchitis. Methods HLA-DRB1 allele frequencies were measured in 37 patients with simple chronic bronchitis and 33 with CWP complicated with chronic bronchitis of Han ethnicity in Shanxi Province using polymerase chain reaction with sequence specific primer, in comparison with those in normal population of the same province. Results Allele frequency of HLA-DRB1*120X was 24.32% in those with simple chronic bronchitis, and that of HLA-DRB1*040X was 22.73% in those with CWP complicated with chronic bronchitis, significantly increased than that in normal people with both P<0.01. There was no significant difference in other alleles between the three groups. Conclusion It suggests that in Han ethnicity of Shanxi Province HLA-DRB1*120X allele frequency is associated with simple chronic bronchitis and that of HLA-DRB1*040X is associated with CWP complicated with chronic bronchitis.
【Key words】 Genes Bronchitis Pneumoconiosis Polymerase chain reaction
慢性支气管炎是由吸烟、空气污染、细菌及病毒感染等长期作用形成的一种气道的炎症性疾病。而煤工尘肺是指煤矿工人长期吸入生产环境中的粉尘所引起的以肺组织纤维化为主的疾病，常合并慢性支气管炎。近年来，有人发现这两种疾病的发生均与遗传有关［1，2］。我们试图应用顺序特异性引物聚合酶链反应(PCR-SSP)技术，观察单纯的慢性支气管炎、煤工尘肺合并慢性支气管炎患者及正[1] [2] 下一页
上一个医学论文： 某矿区接尘工人30年恶性肿瘤发病情况调查
下一个医学论文： 钒钛磁铁矿尘对家兔肺泡巨噬细胞毒作用的体外研究
|
|
|
|
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 基础医学论文 >> 正文