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脑血管意外与血脂水平的研究 |
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许宏伟 杨期东 唐北沙 严新翔
【摘要】 目的 阐明血脂与脑血管病的关系。方法 检测了208例脑血管病患者7项血脂指标。甘油三酯、总胆固醇及高密度脂蛋白胆固醇用酶法测定，载脂蛋白A-I、载脂蛋白B100及脂蛋白(α)用免疫多点定标法测定，低密度脂蛋白胆固醇按公式计算。结果 脑梗塞组甘油三酯、总胆固醇、低密度脂蛋白胆固醇、载脂蛋白B100及脂蛋白(α)水平显著高于对照组，甘油三酯、载脂蛋白B100水平也显著高于脑出血组；脑出血组与对照组血脂水平比较差异无显著。结论 血脂代谢紊乱是脑梗塞的危险因素。
【关键词】 脑梗塞 脑出血 血脂
Studies on Stroke and Blood Lipid Level Xu Hongwei, Yang Qidong, Tang Beisha, et al. Department of Neurology, Institute of Neurology, Xiangya Hospital, Hunan Medical University, Changsha 410008
【Abstract】 Objective To elucidate the relationship between blood lipid levels and cerebrovascular diseases. Methods Seven indicators for blood lipid were determined in 208 patients with cerebrovascular diseases. Triglyceride (TG), total cholesterol (TC) and high-density lipoprotein-cholesterol (HDL-C) were measured with enzyme methods, apolipoprotein A-Ⅰ, apolipoprotein B-100 (Apo-B100) and lipoprotein (α) ［Lp(α)］ were measured with immune multifocal method, and low-density lipoprotein-cholesterol (LDL-C) was calculated according to Friedewald formula. Results Levels of TG, TC, LDL-C, Apo-B100 and Lp(α) in patients with cerebral infarction were significantly higher than those in the controls, and levels of TG and Apo-B100 in them were also significantly higher than those in the patients with cerebral hemorrhage. There was no significant difference in blood lipid levels between the patients with cerebral hemorrhage and the controls. Conclusion It suggests that disturbance of blood lipid metabolism is a risk factor for cerebral infarction.
【Key words】 Cerebral infarction Cerebral hemorrhage Blood lipid
国内外不少关于脑血管病患者存在脂质代谢异常的报道结果不一［1～4］。本研究通过对脑血管病患者血脂的测定和比较，探讨血脂在脑血管病发病中的作用。
对象与方法
1.病例选择：按第二届全国脑血管病会议制定的标准，从本院神经科1995年1月～1997年2 月住院的662例病人中筛选出208例，并经CT或MRI证实。动脉粥样硬化性血栓性脑梗塞(脑梗塞)105例，男68例，女37例，年龄60.68岁±10.86岁；高血压脑出血(脑出血)103例，男68例，女35例，年龄60.43岁±11.14 岁；对照组50例，男33例[1] [2] [3] 下一页
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