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自发性高血压大鼠高血压形成前后肾内小动脉的重建 |
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杨向群 陈尔瑜 姜宗来 章建梁 沙继宏 冀凯宏
【摘要】 目的 探讨肾内小动脉形态学重建与高血压发生的关系。 方法 4周龄和16周龄自发性高血压大鼠(SHR)，使肾内小动脉处于最大舒张状态后，用光镜和电镜配合计算机图像分析法在肾组织切片上测量肾内小动脉的几何形态、中膜平滑肌及其间隙的宽度。 结果 与同龄WKY相比，4周SHR肾内小动脉未发生明显的形态学改变；16周SHR外径在20～50μm之间的小动脉壁厚、壁厚内径比增加，但壁面积未增加，外径在50～200μm之间者3项都显著增加；肾内小动脉中膜平滑肌细胞和平滑肌细胞间隙都显著增加。 结论 SHR肾内小动脉的重建发生在高血压形成之后，外径小于50μm的小动脉的重建可能由于中膜平滑肌细胞的重排所引起的，而外径大于50μm的小动脉的重建则存在中膜平滑肌细胞的增殖和细胞外基质的增加。
【关键词】 小动脉；肾；重建；自发性高血压大鼠
【中图分类号】 R544.102 【文献标识码】 A
【文章编号】 0529-1356(2000)02-133
REMODELING OF RENAL ARTERIOLES IN SPONTANEOUSLY HYPERTENSIVE RATE PRIOR TO AND DURING ESTABLISHED HYPERTENSION
YANG Xiang-qun, CHEN Er-yu, JIANG Zong-lai,JI Kai-hong
（Department of Anatomy, Institute of Biomedical Engineering;）
ZHANG Jian-liang,
（Department of Cardiology, Changhai Hospital;）
SHA Ji-hong,
（Department of Cellular Biology, the Second Military Medical University, Shanghai 200433,China）
【Abstract】 Objective To investigate the relationship between morphological remodeling of renal arterioles and etiology of hypertension. Methods Under dilated conditions, the morphometry of the renal arterioles, and the widths of medial vascular smooth muscle cells (VSMC) and intercellular space were studied on kidney slices by light microscope and electromicroscope combining computer-assistant image analysis system in 4 and 16 weeks old SHR.Results The morphological changes of the renal arterioles in 4 weeks old SHR were not significant compared with age-matched WKY. In 16 weeks old SHR, the wall thickness and ratio of wall thickness to inner diameter of the renal arterioles in 20 to 50 μm outer diameter changed but not the wall area. All the above three parameters increased significantly in renal arterioles of 50 to 200μm outer diameter. The widths of VSMC and intercellular of renal arterioles in 16 weeks old SHR were greater than that in age-matched WKY. Conclusions After the establishment of[1] [2] 下一页
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